HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: SPN90 (Q9NZQ3)
NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)
Gene: NCKIPSD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0008092 - cytoskeletal protein binding GO:0017124 - SH3 domain binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 722
+	Mm
		815099 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		SPN90_MOUSE (1-722): 0: 1138: 88.37
+	Hs
		581065 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		SPN90_HUMAN (1-722): 0: 1137: 100.00
+	Hs
		924910 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SPN90_HUMAN (1-722): 0: 1137: 100.00
+	Hs
		1349276 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		SPN90_HUMAN (1-722): 0: 1137: 100.00
+	Hs
		209182 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		SPN90_HUMAN (1-722): 0: 1137: 100.00
+	Hs
		1078920 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		SPN90_HUMAN (1-722): 0: 1137: 100.00
+	Hs
		557810 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		SPN90_HUMAN (1-722): 0: 1137: 100.00