Protein: DBP8
ATP-dependent RNA helicase DBP8 (EC 3.6.4.13) (DEAD box protein 8)

Gene: DBP8
Organism: Saccharomyces cerevisiae S288C
Interactions: 158
UniProt ID: P38719

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678385

PWP2
Periodic tryptophan protein 2

3

14

High-throughput

0.855

High

802900

DHR1
Probable ATP-dependent RNA helicase DHR1

2

11

High-throughput

0.754

High

779123

DHR2
Probable ATP-dependent RNA helicase DHR2

1

6

High-throughput

0.752

High

802885

ESF2
Pre-rRNA-processing protein ESF2

4

3

Small-scale

0.707

High

518283

IF4A
ATP-dependent RNA helicase eIF4A

1

17

High-throughput

0.691

High

601034

RL8A
Large ribosomal subunit protein eL8A

1

4

High-throughput

0.691

High

798203

ENP1
Essential nuclear protein 1

3

5

Small-scale

0.640

High

802858

RPN1
26S proteasome regulatory subunit RPN1

2

2

High-throughput

0.628

High

632666

DBP4
ATP-dependent RNA helicase HCA4

1

19

High-throughput

0.618

High

682269

SPB4
ATP-dependent rRNA helicase SPB4

1

18

High-throughput

0.618

High

754273

DCA13
Protein SOF1

1

14

High-throughput

0.618

High

792024

GBLP
Small ribosomal subunit protein RACK1

1

17

High-throughput

0.618

High

802864

UTP7
U3 small nucleolar RNA-associated protein 7

1

12

High-throughput

0.618

High

802879

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.618

High

802896

UTP17
NET1-associated nuclear protein 1

1

9

High-throughput

0.618

High

802901

UTP15
U3 small nucleolar RNA-associated protein 15

1

13

High-throughput

0.618

High

802905

UTP13
U3 small nucleolar RNA-associated protein 13

1

20

High-throughput

0.618

High

802911

UTP4
U3 small nucleolar RNA-associated protein 4

1

14

High-throughput

0.618

High

802925

DBP10
ATP-dependent RNA helicase DBP10

1

17

High-throughput

0.618

High

802926

CMR1
DNA damage-binding protein CMR1

1

12

High-throughput

0.618

High

802921

SAS10
Something about silencing protein 10

2

1

High-throughput

0.614

High

435066

RS3
Small ribosomal subunit protein uS3

2

6

High-throughput

0.611

High

638717

RIR1
Ribonucleoside-diphosphate reductase large chain 1

2

0

High-throughput

0.602

High

802867

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.586

High

512988

RS8A
Small ribosomal subunit protein eS8A

2

5

High-throughput

0.584

High

677378

KRR1
KRR1 small subunit processome component

2

4

High-throughput

0.584

High

802865

IMB4
Importin subunit beta-4

2

5

High-throughput

0.584

High

802874

UTP10
U3 small nucleolar RNA-associated protein 10

2

4

High-throughput

0.584

High

802877

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

2

Small-scale

0.584

High

802890

ACT
Actin

2

5

High-throughput

0.584

High

410108

RL25
Large ribosomal subunit protein uL23

2

4

High-throughput

0.571

High

802891

H3
Histone H3

2

14

High-throughput

0.571

High

383681

RS17A
Small ribosomal subunit protein eS17A

2

5

High-throughput

0.558

High

503022

RS22A
Small ribosomal subunit protein uS8A

2

6

High-throughput

0.558

High

802883

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.558

High

523829

HSP71
Heat shock protein SSA1

2

13

High-throughput

0.552

High

544740

SSB1
Ribosome-associated molecular chaperone SSB1

2

12

High-throughput

0.552

High

392676

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.541

High

399365

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

2

High-throughput

0.536

High

427259

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

434363

RL15A
Large ribosomal subunit protein eL15A

1

2

High-throughput

0.536

High

531321

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

531723

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.536

High

569999

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.536

High

597451

EF3A
Elongation factor 3A

1

9

High-throughput

0.536

High

598858

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

3

High-throughput

0.536

High

621363

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.536

High

694132

CDC15
Cell division control protein 15

1

7

High-throughput

0.536

High

701520

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

1

High-throughput

0.536

High

721913

XPO1
Exportin-1

1

16

High-throughput

0.536

High

796147

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.536

High

802860

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.536

High

802861

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.536

High

802863

ARB1
ABC transporter ATP-binding protein ARB1

1

7

High-throughput

0.536

High

802881

ACS2
Acetyl-coenzyme A synthetase 2

1

1

High-throughput

0.536

High

802888

EF3B
Elongation factor 3B

1

9

High-throughput

0.536

High

802894

RL6A
Large ribosomal subunit protein eL6A

1

3

High-throughput

0.536

High

802918

NEW1
[NU+] prion formation protein 1

1

9

High-throughput

0.536

High

365033

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

464324

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

488606

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

802897

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.513

High

518011

SSBP1
Single-stranded nucleic acid-binding protein

1

10

High-throughput

0.500

High

599013

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

3

High-throughput

0.500

High

679640

CDC48
Cell division control protein 48

1

6

High-throughput

0.500

High

709737

BMH1
Protein BMH1

1

5

High-throughput

0.500

High

802916

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

2

High-throughput

0.500

High

802919

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

2

High-throughput

0.500

High

394521

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.489

High

511789

RS24A
Small ribosomal subunit protein eS24A

1

3

High-throughput

0.489

High

635958

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

734090

EF2
Elongation factor 2

1

9

High-throughput

0.489

High

802871

COPB
Coatomer subunit beta

1

1

High-throughput

0.489

High

802908

THI22
Thiamine biosynthesis protein THI22

1

2

High-throughput

0.489

High

626719

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

149742

RS9A
Small ribosomal subunit protein uS4A

1

6

High-throughput

0.479

High

432564

RL7A
Large ribosomal subunit protein uL30A

1

9

High-throughput

0.479

High

433620

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

435941

RS13
Small ribosomal subunit protein uS15

1

5

High-throughput

0.479

High

436399

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

3

High-throughput

0.479

High

441887

RS14A
Small ribosomal subunit protein uS11A

1

5

High-throughput

0.479

High

455041

RS19A
Small ribosomal subunit protein eS19A

1

6

High-throughput

0.479

High

512419

RS6A
Small ribosomal subunit protein eS6A

1

6

High-throughput

0.479

High

513858

RS11B
Small ribosomal subunit protein uS17B

1

5

High-throughput

0.479

High

514619

RS18A
Small ribosomal subunit protein uS13A

1

5

High-throughput

0.479

High

561470

TBP
TATA-box-binding protein

1

2

High-throughput

0.479

High

674600

RS2
Small ribosomal subunit protein uS5

1

8

High-throughput

0.479

High

689432

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

707002

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

734959

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

747342

RSSA1
Small ribosomal subunit protein uS2A

1

10

High-throughput

0.479

High

753349

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.479

High

778307

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

802869

DSN1
Kinetochore-associated protein DSN1

1

4

High-throughput

0.479

High

802878

NOL10
Ribosome biogenesis protein ENP2

1

2

High-throughput

0.479

High

802886

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

802887

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

4

High-throughput

0.479

High

802893

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.479

High

802895

UTP6
U3 small nucleolar RNA-associated protein 6

1

1

High-throughput

0.479

High

802898

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

802899

UTP5
U3 small nucleolar RNA-associated protein 5

1

13

High-throughput

0.479

High

802902

UTP14
U3 small nucleolar RNA-associated protein 14

1

4

High-throughput

0.479

High

802904

RRP5
rRNA biogenesis protein RRP5

1

11

High-throughput

0.479

High

802906

UTP21
U3 small nucleolar RNA-associated protein 21

1

12

High-throughput

0.479

High

802907

ESF1
Pre-rRNA-processing protein ESF1

1

3

High-throughput

0.479

High

802909

NOC4
Nucleolar complex protein 4

1

8

High-throughput

0.479

High

802910

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

802915

RCL1
rRNA processing protein RCL1

1

1

High-throughput

0.479

High

802917

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.479

High

802922

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

802924

UTP12
U3 small nucleolar RNA-associated protein 12

1

14

High-throughput

0.479

High

802927

RRP12
Ribosomal RNA-processing protein 12

1

1

High-throughput

0.479

High

802928

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

802912

IMH1
Golgin IMH1

1

10

High-throughput

0.470

High

758367

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

802859

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

802868

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

802884

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

405085

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.457

High

381091

H2B1
Histone H2B.1

1

9

High-throughput

0.445

High

453579

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

510457

HSP77
Import motor subunit, mitochondrial

1

11

High-throughput

0.445

High

526601

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

684709

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.445

High

802613

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.445

High

802866

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

802873

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.445

High

802875

GCN20
Protein GCN20

1

6

High-throughput

0.445

High

802876

RSSA2
Small ribosomal subunit protein uS2B

1

10

High-throughput

0.445

High

802920

MDN1
Midasin

1

5

High-throughput

0.445

High

802923

RL7B
Large ribosomal subunit protein uL30B

1

9

High-throughput

0.445

High

504191

RL31A
Large ribosomal subunit protein eL31A

1

7

High-throughput

0.437

High

511187

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

802147

RS20
Small ribosomal subunit protein uS10

1

7

High-throughput

0.437

High

802862

LAA1
AP-1 accessory protein LAA1

1

5

High-throughput

0.437

High

802882

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.437

High

802892

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

802903

POB3
FACT complex subunit POB3

1

6

High-throughput

0.437

High

802913

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

439326

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.426

High

486162

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

592228

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

450580

FAS1
Fatty acid synthase subunit beta

1

1

High-throughput

0.407

High

575446

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.407

High

755088

GCN1
eIF-2-alpha kinase activator GCN1

1

11

High-throughput

0.407

High

802870

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.407

High

802872

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

780814

YKH5
Uncharacterized protein YKL075C

1

0

High-throughput

0.282

High

368163

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.279

Low

779402

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

788416

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.279

Low

802914

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.279

Low

594939

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.261

Low

802889

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.261

Low

453021

CBP8
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.249

Low

784045

RM11
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.249

Low

386698

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

802880

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025