HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: CASL (Q14511)
Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
Gene: NEDD9

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	9020138, 9820532, 9498705, 9162067
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH3_2~SH3_9
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016477 - cell migration GO:1900026 - positive regulation of substrate adhesion-dependent cell spreading
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 834
+	Hs
		802600 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		CASL_HUMAN (1-834): 0: 614: 100.00
+	Mm
		192348 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		CASL_MOUSE (1-834): 0: 612: 88.85
+	Hs
		557691 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		CASL_HUMAN (1-834): 0: 614: 100.00
+	Hs
		802811 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		BCAR1_HUMAN (1-832): 3e-84: 289: 33.44
+	Mm
		815091 CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70		BCAR1_MOUSE (1-832): 1.75e-82: 284: 32.86
+	Rn
		1144370 CRK_RAT (3-302): 8.22e-54: 179: 54.89		BCAR1_RAT (4-832): 1.74e-83: 289: 33.30
+	Hs
		802545 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		BCAR1_HUMAN (1-832): 3e-84: 289: 33.44
+	Mm
		1142189 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		BCAR1_MOUSE (1-832): 1.75e-82: 284: 32.86
+	Hs
		802742 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		CASS4_HUMAN (4-829): 2.76e-79: 273: 22.64
+	Hs
		557645 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		BCAR1_HUMAN (1-832): 3e-84: 289: 33.44
+	Hs
		802885 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		SH3K1_HUMAN (8-74): 1.37e-11: 70.1: 31.34
+	Hs
		199507 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		802689 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		SH3K1_HUMAN (8-74): 1.37e-11: 70.1: 31.34
+	Hs
		974160 ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44		DYST_HUMAN (403-825): 1.13e-34: 146: 11.63
+	Hs
		199502 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Ce
		136804 VAV_CAEEL (14-185): 2.45e-26: 111: 21.91		UNC89_CAEEL (66-415): 4.87e-13: 75.9: 12.76
+	Mm
		1208602 PLCG2_MOUSE (5-192): 3.94e-27: 113: 18.72		SH3K1_MOUSE (10-87): 7.86e-12: 70.9: 25.64
+	Hs
		199501 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		1285205 ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44		SH3K1_HUMAN (8-74): 1.37e-11: 70.1: 31.34
+	Hs
		203208 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		SYNJ1_HUMAN (52-433): 1.04e-12: 74.4: 10.17