HitPredict

Interactor 1: NSF (P46459)
Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)
Gene: NSF

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 744 Hs			1 100
+	Hs
		261641 NSF_HUMAN (1-744): 0: 572: 100.00		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		803923 NSF_HUMAN (1-744): 0: 572: 100.00		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		803893 NSF_HUMAN (1-744): 0: 572: 100.00		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Dm
		870075 NSF2_DROME (5-742): 6.55e-166: 498: 63.21		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Sc
		578512 SEC18_YEAST (4-721): 5.88e-146: 447: 44.22		SNC1_YEAST (2-79): 5.22e-23: 86.9: 26.92
+	Hs
		874800 TERA_HUMAN (146-479): 5.59e-69: 244: 31.05		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07