HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: ANR44 (Q8N8A2)
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44)
Gene: ANKRD44

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Ank, Ank~Ank_2, Ank~Ank_4, Ank_2~Ank_2, Ank_2~Ank_4, Ank_4~Ank_4
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 993
+	Hs
		1237561 NOTC3_HUMAN (1-2014): 0: 679: 27.54		ANR44_HUMAN (706-993): 1.09e-44: 177: 25.69
+	Hs
		167042 NOTC3_HUMAN (1-2014): 0: 679: 27.54		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24
+	Dm
		1187207 Q7YSQ1_DROME (1785-2269): 7.85e-112: 369: 41.30		Q8SWY2_DROME (414-992): 2.48e-119: 391: 23.79
+	Mm
		103608 ANK2_MOUSE (1648-2151): 3.76e-101: 368: 16.60		ANK3_MOUSE (572-992): 6.57e-95: 333: 26.39
+	Mm
		103591 ANK3_MOUSE (1572-2114): 3.81e-99: 359: 17.42		ANK3_MOUSE (572-992): 6.57e-95: 333: 26.39
+	Hs
		310030 TNKS1_HUMAN (1588-2117): 1.38e-80: 296: 17.74		TNKS1_HUMAN (604-990): 1.76e-70: 258: 25.64
+	Hs
		1237559 ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72		ANFY1_HUMAN (2-536): 1.38e-78: 281: 19.57
+	Hs
		166913 ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24
+	Hs
		257652 ANR17_HUMAN (1919-2553): 8.85e-80: 297: 13.87		ANKH1_HUMAN (693-992): 4.95e-42: 170: 21.82
+	Hs
		166919 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24
+	Hs
		167036 ANR50_HUMAN (1862-2553): 1.06e-91: 332: 15.85		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24
+	Dm
		65546 NOTCH_DROME (1984-2545): 4.18e-12: 74.6: 12.78		A8JNM5_DROME (469-992): 3.22e-93: 328: 21.26
+	Hs
		166869 TNKS1_HUMAN (1588-2117): 1.38e-80: 296: 17.74		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24
+	Hs
		166969 ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24
+	Hs
		166971 ANR52_HUMAN (1998-2492): 2.36e-64: 242: 13.80		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24
+	Hs
		980449 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ANR44_HUMAN (706-993): 1.09e-44: 177: 25.69
+	Hs
		166914 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ANR28_HUMAN (1-148): 9.57e-21: 100: 23.24