Protein: ACON
Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

Gene: ACON, ACO2
Organism: Homo sapiens
Interactions: 171
UniProt ID: Q99798

Gene Ontology (top 5):
GO:0003994 - aconitate hydratase activity
GO:0005506 - iron ion binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1162511

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

0

Small-scale

0.613

High

242712

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

460621

SYEP
Bifunctional glutamate/proline--tRNA ligase

2

1

High-throughput

0.584

High

801492

HSPA9
Stress-70 protein, mitochondrial

2

11

High-throughput

0.584

High

933715

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

0

Small-scale

0.559

High

1137976

TNIP1
TNFAIP3-interacting protein 1

2

0

High-throughput

0.559

High

619903

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.549

High

530280

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.536

High

1310340

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.530

High

361342

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

363772

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.513

High

422976

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

955518

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.501

High

1407347

TCIM
Transcriptional and immune response regulator

1

0

High-throughput

0.493

High

414491

P53
Cellular tumor antigen p53

1

0

High-throughput

0.479

High

162673

ANM5
Protein arginine N-methyltransferase 5

1

2

High-throughput

0.479

High

224348

BUB3
Mitotic checkpoint protein BUB3

1

1

High-throughput

0.479

High

279877

CISY
Citrate synthase, mitochondrial

1

5

High-throughput

0.479

High

412506

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

457643

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

471204

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.479

High

532895

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

535453

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

537781

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

550437

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.479

High

576823

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

635549

NEBU
Nebulin

1

1

High-throughput

0.479

High

658362

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

660148

COF1
Cofilin-1

1

1

High-throughput

0.479

High

673943

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

680479

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

7

High-throughput

0.479

High

699840

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.479

High

720796

PUR8
Adenylosuccinate lyase

1

3

High-throughput

0.479

High

724509

GDIA
Rab GDP dissociation inhibitor alpha

1

1

High-throughput

0.479

High

729420

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.479

High

732388

PRDX2
Peroxiredoxin-2

1

4

High-throughput

0.479

High

761002

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

2

High-throughput

0.479

High

764990

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

807551

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.479

High

828912

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

860333

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

877373

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

3

High-throughput

0.479

High

934150

XPO2
Exportin-2

1

1

High-throughput

0.479

High

935050

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

954247

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

968424

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

1

High-throughput

0.479

High

969673

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.479

High

972535

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.479

High

978682

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

981937

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

983562

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

High-throughput

0.479

High

984932

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

987172

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.479

High

992930

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

993308

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.479

High

1024439

S25A3
Solute carrier family 25 member 3

1

3

High-throughput

0.479

High

1028857

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.479

High

1031124

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

1

High-throughput

0.479

High

1057240

PRDX1
Peroxiredoxin-1

1

4

High-throughput

0.479

High

1090509

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

1102896

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.479

High

1227339

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1280439

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1365218

HS105
Heat shock protein 105 kDa

1

8

High-throughput

0.479

High

1370995

TNPO1
Transportin-1

1

1

High-throughput

0.479

High

1388028

ASB9
Ankyrin repeat and SOCS box protein 9

1

2

High-throughput

0.479

High

1407345

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

1407348

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.479

High

1407353

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1407354

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

4

High-throughput

0.479

High

1407358

RUVB2
RuvB-like 2

1

4

High-throughput

0.479

High

1407359

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

1407360

FND3A
Fibronectin type-III domain-containing protein 3A

1

3

High-throughput

0.479

High

123432

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

347279

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

386148

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

405327

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

446463

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

558362

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

586850

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

610848

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.458

High

697631

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

716453

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

716951

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

852002

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

859414

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

860592

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

867377

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

883319

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

895001

EMD
Emerin

1

0

High-throughput

0.458

High

905072

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

941249

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

952633

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.458

High

970968

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

972943

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

973279

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

973553

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.458

High

977346

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.458

High

982788

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

983194

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

984514

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

985836

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

1107137

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1108081

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1140747

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1142637

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1146786

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1164527

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1314042

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

1339150

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1407351

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

142401

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.445

High

593609

GDC
Solute carrier family 25 member 16

1

1

High-throughput

0.445

High

944048

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1397150

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

1

High-throughput

0.445

High

1407342

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.445

High

1407357

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

505607

ATX1L
Ataxin-1-like

1

1

High-throughput

0.439

High

106542

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

162856

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

2

High-throughput

0.437

High

207633

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.437

High

224784

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.437

High

353525

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

601420

RHOQ
Rho-related GTP-binding protein RhoQ

1

2

High-throughput

0.437

High

615582

NELFE
Negative elongation factor E

1

1

High-throughput

0.437

High

696323

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

699043

CALX
Calnexin

1

1

High-throughput

0.437

High

775746

CYLC1
Cylicin-1

1

1

High-throughput

0.437

High

964436

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.437

High

998732

H31
Histone H3.1

1

1

High-throughput

0.437

High

1108677

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.437

High

1118142

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.437

High

1127111

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

1255235

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1324058

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

1407338

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.437

High

1407344

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.437

High

1407356

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.437

High

369208

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

653527

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1104067

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

1407339

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

1407349

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1407361

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.426

High

1407346

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.407

High

1407352

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

0

High-throughput

0.282

High

1351867

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.279

Low

1407343

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.279

Low

372959

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

474239

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.249

Low

565456

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

589511

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

768994

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

832784

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

837810

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

879392

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

965187

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1155700

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1218985

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

1226797

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.249

Low

1369052

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.249

Low

1407340

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.249

Low

1407350

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

1407355

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

1407362

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low

827473

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.238

Low

330289

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1047330

P
P protein

1

0

High-throughput

0.232

Low

1308786

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low

1358186

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

1407341

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025