HitPredict

Interactor 1: MPC2 (P38857)
Mitochondrial pyruvate carrier 2 (MPC2)
Gene: MPC2

Interactor 2: MPC3 (P53311)
Mitochondrial pyruvate carrier 3 (MPC3) (Protein FMP43)
Gene: MPC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	22628558
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0006850 - pyruvate import into mitochondria GO:0050833 - pyruvate transmembrane transporter activity GO:0098800 - inner mitochondrial membrane protein complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 129 Sc			1 146
+	Sc
		917773 MPC1_YEAST (1-124): 7.03e-58: 177: 22.31		MPC3_YEAST (1-146): 8.62e-79: 231: 100.00
+	Sc
		919534 MPC3_YEAST (1-118): 1.38e-57: 176: 77.97		MPC3_YEAST (1-146): 8.62e-79: 231: 100.00
+	Sc
		806099 MPC2_YEAST (1-129): 1.61e-64: 193: 100.00		MPC2_YEAST (1-117): 3.57e-58: 178: 78.63
+	Sc
		806102 MPC2_YEAST (1-129): 1.61e-64: 193: 100.00		MPC1_YEAST (1-109): 1.34e-48: 154: 22.61
+	Sc
		917772 MPC1_YEAST (1-124): 7.03e-58: 177: 22.31		MPC1_YEAST (1-109): 1.34e-48: 154: 22.61
+	Hs
		339241 MPC2_HUMAN (10-100): 3.25e-44: 142: 48.35		MPC2_HUMAN (6-100): 3.83e-44: 142: 49.47
+	Hs
		339300 MPC2_HUMAN (10-100): 3.25e-44: 142: 48.35		MPC1_HUMAN (22-106): 3.68e-40: 132: 27.06
+	Hs
		339247 MPC2_HUMAN (10-100): 3.25e-44: 142: 48.35		MPC1L_HUMAN (22-95): 5.37e-32: 112: 28.38