HitPredict

Interactor 1: MPC1 (P53157)
Mitochondrial pyruvate carrier 1 (MPC1) (Protein FMP37)
Gene: MPC1

Interactor 2: MPC3 (P53311)
Mitochondrial pyruvate carrier 3 (MPC3) (Protein FMP43)
Gene: MPC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	22628558, 24244496, 25672363, 30979775, 35278701
Identification Methods	tandem affinity purification, affinity chromatography technology, biochemical, cross-linking study, blue native page, anti tag coimmunoprecipitation, molecular sieving
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0006850 - pyruvate import into mitochondria GO:0050833 - pyruvate transmembrane transporter activity GO:0098800 - inner mitochondrial membrane protein complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 130 Sc			1 146
+	Sc
		806103 MPC2_YEAST (1-106): 7.92e-42: 136: 25.47		MPC3_YEAST (1-146): 8.62e-79: 231: 100.00
+	Sc
		919534 MPC3_YEAST (1-106): 3.14e-41: 135: 22.64		MPC3_YEAST (1-146): 8.62e-79: 231: 100.00
+	Sc
		806102 MPC1_YEAST (1-130): 8.86e-60: 181: 100.00		MPC2_YEAST (1-117): 3.57e-58: 178: 78.63
+	Sc
		917772 MPC1_YEAST (1-130): 8.86e-60: 181: 100.00		MPC1_YEAST (1-109): 1.34e-48: 154: 22.61
+	Sc
		806099 MPC2_YEAST (1-106): 7.92e-42: 136: 25.47		MPC2_YEAST (1-117): 3.57e-58: 178: 78.63
+	Hs
		339300 MPC1_HUMAN (8-106): 6.62e-45: 143: 52.53		MPC2_HUMAN (6-100): 3.83e-44: 142: 49.47
+	Hs
		339247 MPC1L_HUMAN (11-118): 1.97e-38: 127: 44.44		MPC2_HUMAN (6-100): 3.83e-44: 142: 49.47
+	Hs
		339241 MPC2_HUMAN (5-112): 7.82e-38: 126: 19.44		MPC2_HUMAN (6-100): 3.83e-44: 142: 49.47