Protein: MPC2
Mitochondrial pyruvate carrier 2 (Brain protein 44)

Gene: MPC2
Organism: Homo sapiens
Interactions: 71
UniProt ID: O95563

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006086 - pyruvate decarboxylation to acetyl-CoA
GO:0006850 - pyruvate import into mitochondria

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

339300

MPC1
Mitochondrial pyruvate carrier 1

6

8

Small-scale

0.729

High

339294

S39A9
Zinc transporter ZIP9

2

2

High-throughput

0.628

High

339241

MPC2
Mitochondrial pyruvate carrier 2

2

8

High-throughput

0.606

High

257527

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

2

0

High-throughput

0.580

High

339272

MIC10
MICOS complex subunit MIC10

2

0

High-throughput

0.580

High

339293

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.580

High

339255

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.574

High

339247

MPC1L
Mitochondrial pyruvate carrier 1-like protein

1

8

Small-scale

0.566

High

339256

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.536

High

339248

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

339279

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

339260

H11
Histone H1.1

1

0

High-throughput

0.493

High

135436

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.493

High

339252

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.493

High

339265

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.489

High

339268

S39AC
Zinc transporter ZIP12

1

2

High-throughput

0.489

High

292047

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

339271

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

Small-scale

0.479

High

137600

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

274957

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

339242

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

339249

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

339251

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

339270

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

339277

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

339285

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.458

High

339287

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

339288

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.458

High

339289

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

339291

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

339292

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

339296

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

339257

BI1
Bax inhibitor 1

1

0

High-throughput

0.426

High

339264

S39AE
Metal cation symporter ZIP14

1

2

High-throughput

0.407

High

339263

FLOT2
Flotillin-2

3

0

High-throughput

0.347

High

339259

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

0

High-throughput

0.328

High

339275

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

2

0

High-throughput

0.328

High

339282

TM171
Transmembrane protein 171

2

0

High-throughput

0.328

High

339244

APOC1
Apolipoprotein C-I

2

0

High-throughput

0.316

High

339262

SNX1
Sorting nexin-1

2

0

High-throughput

0.316

High

339266

SYT16
Synaptotagmin-16

2

0

High-throughput

0.316

High

339269

TEX44
Testis-expressed protein 44

2

0

High-throughput

0.316

High

339273

RHBD2
Rhomboid domain-containing protein 2

2

0

High-throughput

0.316

High

339295

SPG21
Maspardin

2

0

High-throughput

0.316

High

339297

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.316

High

339245

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

339246

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.282

High

131262

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.279

Low

339254

INGR2
Interferon gamma receptor 2

1

0

High-throughput

0.279

Low

339261

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.279

Low

339267

CL12B
C-type lectin domain family 12 member B

1

0

High-throughput

0.279

Low

339280

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

339283

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

339286

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.279

Low

339298

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

0

High-throughput

0.279

Low

339301

SO1B1
Solute carrier organic anion transporter family member 1B1

1

0

High-throughput

0.279

Low

339258

NC2B
Protein Dr1

1

0

High-throughput

0.268

Low

339281

BRK1
Protein BRICK1

1

0

High-throughput

0.268

Low

339299

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.268

Low

164208

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

339243

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

339253

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

339276

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

58780

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

248821

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

339250

UD2B7
UDP-glucuronosyltransferase 2B7

1

0

Small-scale

0.232

Low

339274

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

339278

SCD5
Stearoyl-CoA desaturase 5

1

0

High-throughput

0.232

Low

339284

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

339290

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025