HitPredict

Interactor 1: BRCA1 (B6VQ60)
Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BRCA1)
Gene: brc-1

Interactor 2: UBC2 (P35129)
Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Lethal protein 70) (Ubiquitin carrier protein 2) (Ubiquitin-protein ligase 2)
Gene: let-70

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	16628214
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0005694 - chromosome GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 612 Ce			1 147
+	Hs
		537142 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UB2D4_HUMAN (1-147): 3.06e-83: 242: 92.52
+	Hs
		584907 RO52_HUMAN (6-430): 1.59e-73: 245: 14.49		UB2D1_HUMAN (1-147): 2.25e-82: 240: 89.12
+	Hs
		536760 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UB2D1_HUMAN (1-147): 2.25e-82: 240: 89.12
+	Hs
		584923 RO52_HUMAN (6-430): 1.59e-73: 245: 14.49		UB2D2_HUMAN (1-147): 5.79e-82: 239: 93.88
+	Hs
		536779 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UB2D2_HUMAN (1-147): 5.79e-82: 239: 93.88
+	Hs
		584916 RO52_HUMAN (6-430): 1.59e-73: 245: 14.49		UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52
+	Hs
		536772 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52
+	Hs
		849406 TRI11_HUMAN (6-395): 3e-71: 239: 14.80		UB2D1_HUMAN (1-147): 2.25e-82: 240: 89.12
+	Hs
		895851 TRI58_HUMAN (6-398): 9.34e-73: 243: 13.50		UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52
+	Hs
		895815 TRI68_HUMAN (6-424): 5.13e-71: 239: 16.74		UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52
+	Hs
		895876 TRI11_HUMAN (6-395): 3e-71: 239: 14.80		UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52
+	Hs
		536996 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UB2E2_HUMAN (4-146): 3.55e-74: 221: 66.43
+	Hs
		536965 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UB2E3_HUMAN (4-146): 1.22e-73: 220: 66.43
+	Hs
		584910 RO52_HUMAN (6-430): 1.59e-73: 245: 14.49		UB2E1_HUMAN (4-146): 4.54e-72: 216: 66.43
+	Hs
		536763 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UB2E1_HUMAN (4-146): 4.54e-72: 216: 66.43
+	Hs
		851867 TRI11_HUMAN (6-395): 3e-71: 239: 14.80		UB2E1_HUMAN (4-146): 4.54e-72: 216: 66.43
+	Hs
		536757 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UBE2A_HUMAN (2-144): 1.34e-70: 210: 39.16
+	Hs
		584918 RO52_HUMAN (6-430): 1.59e-73: 245: 14.49		UBE2N_HUMAN (4-147): 1.25e-68: 205: 47.22
+	Hs
		536774 TRI27_HUMAN (6-384): 5.87e-73: 244: 15.35		UBE2N_HUMAN (4-147): 1.25e-68: 205: 47.22
+	Hs
		896517 TRI11_HUMAN (6-395): 3e-71: 239: 14.80		UBE2N_HUMAN (4-147): 1.25e-68: 205: 47.22