Protein: CKS1
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)

Gene: CKS1, CKS1B
Organism: Homo sapiens
Interactions: 98
UniProt ID: P61024

Gene Ontology (top 5):
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0005654 - nucleoplasm
GO:0007346 - regulation of mitotic cell cycle
GO:0019005 - SCF ubiquitin ligase complex
GO:0019901 - protein kinase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667697

CDK2
Cyclin-dependent kinase 2

18

20

Small-scale

0.987

High

443287

CDK1
Cyclin-dependent kinase 1

13

20

Small-scale

0.984

High

956646

CDK3
Cyclin-dependent kinase 3

7

20

Small-scale

0.965

High

956684

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

3

5

High-throughput

0.871

High

753909

CKS2
Cyclin-dependent kinases regulatory subunit 2

2

5

High-throughput

0.811

High

956657

SKP2
S-phase kinase-associated protein 2

17

2

Small-scale

0.765

High

956643

SKP1
S-phase kinase-associated protein 1

9

1

Small-scale

0.751

High

629093

CCNA2
Cyclin-A2

8

20

Small-scale

0.749

High

857295

CDN1B
Cyclin-dependent kinase inhibitor 1B

6

3

Small-scale

0.731

High

956699

CILK1
Serine/threonine-protein kinase ICK

2

20

High-throughput

0.726

High

573785

CCNB1
G2/mitotic-specific cyclin-B1

5

20

Small-scale

0.718

High

509961

TRI49
Tripartite motif-containing protein 49

5

2

High-throughput

0.717

High

808004

CDN1A
Cyclin-dependent kinase inhibitor 1

4

3

High-throughput

0.699

High

956642

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

5

High-throughput

0.698

High

956655

CDC20
Cell division cycle protein 20 homolog

4

6

Small-scale

0.691

High

956659

IKZF1
DNA-binding protein Ikaros

3

3

High-throughput

0.675

High

956660

CUL1
Cullin-1

4

0

Small-scale

0.672

High

325478

CCNB2
G2/mitotic-specific cyclin-B2

3

20

Small-scale

0.670

High

956645

XIAP
E3 ubiquitin-protein ligase XIAP

4

0

High-throughput

0.668

High

66879

SPDE4
Speedy protein E4

3

5

High-throughput

0.665

High

956650

ARI5A
AT-rich interactive domain-containing protein 5A

3

0

High-throughput

0.646

High

956696

FZR1
Fizzy-related protein homolog

3

6

Small-scale

0.633

High

284299

GEMI
Geminin

2

1

High-throughput

0.628

High

355343

CCNE2
G1/S-specific cyclin-E2

2

20

High-throughput

0.628

High

666970

CCNE1
G1/S-specific cyclin-E1

2

20

High-throughput

0.628

High

956653

EF1A2
Elongation factor 1-alpha 2

2

2

High-throughput

0.628

High

956685

CDT1
DNA replication factor Cdt1

2

1

High-throughput

0.628

High

956647

CDK5
Cyclin-dependent kinase 5

1

20

High-throughput

0.618

High

956689

CDK12
Cyclin-dependent kinase 12

1

16

High-throughput

0.618

High

587040

ITF2
Transcription factor 4

3

1

High-throughput

0.616

High

893681

MEOX1
Homeobox protein MOX-1

3

6

High-throughput

0.616

High

666818

CCNC
Cyclin-C

2

20

High-throughput

0.606

High

685146

PAX6
Paired box protein Pax-6

2

2

High-throughput

0.606

High

956648

PAX5
Paired box protein Pax-5

2

2

High-throughput

0.606

High

956682

ASPP1
Apoptosis-stimulating of p53 protein 1

2

1

High-throughput

0.606

High

956683

HTF4
Transcription factor 12

2

1

High-throughput

0.606

High

956695

IKZF3
Zinc finger protein Aiolos

2

3

High-throughput

0.606

High

956673

CSN6
COP9 signalosome complex subunit 6

2

0

High-throughput

0.602

High

956669

SPDYC
Speedy protein C

2

5

High-throughput

0.601

High

956665

SMTL2
Smoothelin-like protein 2

3

1

High-throughput

0.587

High

269169

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

956654

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

956656

STF1
Steroidogenic factor 1

2

0

High-throughput

0.580

High

956661

SRTD2
SERTA domain-containing protein 2

2

0

High-throughput

0.580

High

956664

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

2

0

High-throughput

0.580

High

956686

IKZF5
Zinc finger protein Pegasus

2

3

High-throughput

0.574

High

571914

TRI27
Zinc finger protein RFP

1

2

High-throughput

0.573

High

509969

TR49C
Tripartite motif-containing protein 49C

2

2

High-throughput

0.553

High

956662

TRI14
Tripartite motif-containing protein 14

2

1

High-throughput

0.553

High

956652

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

651124

CCNO
Cyclin-O

1

20

High-throughput

0.536

High

158964

CDX4
Homeobox protein CDX-4

1

6

High-throughput

0.523

High

685835

KRA59
Keratin-associated protein 5-9

1

1

High-throughput

0.523

High

956679

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

956697

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

461329

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.501

High

718531

CDC27
Cell division cycle protein 27 homolog

1

2

Small-scale

0.501

High

956644

CCNA1
Cyclin-A1

1

20

Small-scale

0.501

High

956663

CDC37
Hsp90 co-chaperone Cdc37

1

1

Small-scale

0.501

High

956687

PKHG2
Pleckstrin homology domain-containing family G member 2

1

1

High-throughput

0.489

High

664698

CCND1
G1/S-specific cyclin-D1

1

20

Small-scale

0.479

High

956649

KMT2A
Histone-lysine N-methyltransferase 2A

1

1

Small-scale

0.479

High

956658

ORC1
Origin recognition complex subunit 1

1

1

Small-scale

0.479

High

956672

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.470

High

578434

BRAF
Serine/threonine-protein kinase B-raf

1

1

High-throughput

0.462

High

956671

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

Small-scale

0.460

High

371617

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

956674

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

956676

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

956691

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

450967

LDHB
L-lactate dehydrogenase B chain

1

1

Small-scale

0.457

High

956651

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.457

High

956666

SPDE7
Putative speedy protein E7

1

5

High-throughput

0.445

High

893793

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.439

High

956677

CBY2
Protein chibby homolog 2

3

0

High-throughput

0.352

High

956688

ROP1A
Ropporin-1A

3

0

High-throughput

0.352

High

956692

SEPT3
Neuronal-specific septin-3

3

0

High-throughput

0.352

High

353681

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.316

High

956668

CT451
Cancer/testis antigen family 45 member A1

2

0

High-throughput

0.316

High

956670

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.316

High

956675

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

0

High-throughput

0.316

High

956680

ZBTB9
Zinc finger and BTB domain-containing protein 9

2

0

High-throughput

0.316

High

956681

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

956690

LHX3
LIM/homeobox protein Lhx3

2

0

High-throughput

0.316

High

956693

DCDC2
Doublecortin domain-containing protein 2

2

0

High-throughput

0.316

High

956694

SRTD1
SERTA domain-containing protein 1

2

0

High-throughput

0.316

High

956698

WASF3
Actin-binding protein WASF3

2

0

High-throughput

0.316

High

956700

LZTS1
Leucine zipper putative tumor suppressor 1

2

0

High-throughput

0.316

High

950743

KR109
Keratin-associated protein 10-9

1

0

High-throughput

0.299

High

956678

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.299

High

703923

DUS1
Dual specificity protein phosphatase 1

2

0

Small-scale

0.298

High

326142

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.279

Low

893474

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

High-throughput

0.279

Low

956667

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

107796

SUMO5
Small ubiquitin-related modifier 5

1

0

High-throughput

0.268

Low

128405

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.261

Low

375340

RASK
GTPase KRas

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025