HitPredict

Interactor 1: SMC3 (P47037)
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)
Gene: SMC3

Interactor 2: SCC1 (Q12158)
Sister chromatid cohesion protein 1
Gene: MCD1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 9990856, 11805826, 11805837, 27307603, 26895425, 25748820, 25414305, 29187575, 31225797, 31201089, 17055978, 34259632, 37739959, 20498298, 20153193, 21441928, 23878248, 14614819, 14614818, 11983169 and 16 others

more...
Identification Methods coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation, affinity chromatography technology, pull down, x-ray crystallography, fluorescent resonance energy transfer, biochemical
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms GO:0005634 - nucleus
GO:0007064 - mitotic sister chromatid cohesion
GO:0019901 - protein kinase binding
GO:0030892 - mitotic cohesin complex
GO:0034087 - establishment of mitotic sister chromatid cohesion
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1230
Sc

1 566
+ Sc
+ Xl
+ Xl
+ Xl
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Mm
+ Mm
+ Mm
+ Sp
+ Sp
+ Hs
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024