Protein: AP2A
AP-2 complex subunit alpha (Alpha-adaptin) (Clathrin assembly protein complex 2 alpha large chain) (Clathrin assembly protein large alpha chain)

Gene: AP2A, APL3
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: P38065

Gene Ontology (top 5):
GO:0005935 - cellular bud neck
GO:0006886 - intracellular protein transport
GO:0030122 - AP-2 adaptor complex
GO:0035615 - clathrin adaptor activity
GO:0072583 - clathrin-dependent endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

792681

AP2M
AP-2 complex subunit mu

5

20

High-throughput

0.916

High

792667

AP2S
AP-2 complex subunit sigma

4

20

High-throughput

0.891

High

691604

AP2B
AP-2 complex subunit beta

4

17

Small-scale

0.881

High

792653

AP2A
AP-2 complex subunit alpha

1

15

High-throughput

0.618

High

792664

COPA
Coatomer subunit alpha

1

6

High-throughput

0.618

High

523678

HSP71
Heat shock protein SSA1

3

11

High-throughput

0.578

High

744830

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

8

High-throughput

0.541

High

665811

KPC1
Protein kinase C-like 1

1

3

High-throughput

0.536

High

792657

SSB2
Ribosome-associated molecular chaperone SSB2

2

11

High-throughput

0.504

High

721863

XPO1
Exportin-1

1

18

High-throughput

0.489

High

672647

BPH1
Beige protein homolog 1

1

7

High-throughput

0.479

High

757692

EDE1
EH domain-containing and endocytosis protein 1

1

20

Small-scale

0.479

High

792669

SIZ1
E3 SUMO-protein ligase SIZ1

1

4

High-throughput

0.479

High

792675

VAM6
Vacuolar morphogenesis protein 6

1

7

High-throughput

0.479

High

792680

ENT1
Epsin-1

1

20

Small-scale

0.479

High

792660

ALY2
Arrestin-related trafficking adapter 3

1

6

High-throughput

0.470

High

792659

IRC6
Increased recombination centers protein 6

1

1

High-throughput

0.464

High

642369

MCK1
Protein kinase MCK1

1

5

High-throughput

0.457

High

724288

ZIP1
Synaptonemal complex protein ZIP1

1

2

High-throughput

0.439

High

753067

NIP80
Protein NIP100

1

15

High-throughput

0.439

High

758080

CASP
Protein CASP

1

10

High-throughput

0.439

High

706856

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

709709

BMH1
Protein BMH1

1

3

High-throughput

0.437

High

792654

NU170
Nucleoporin NUP170

1

3

High-throughput

0.437

High

792658

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.437

High

792666

H3
Histone H3

1

2

High-throughput

0.437

High

792668

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

792672

RSE1
Pre-mRNA-splicing factor RSE1

1

2

High-throughput

0.437

High

792676

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.437

High

792679

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.437

High

383656

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.407

High

394470

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

427235

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.407

High

433189

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.407

High

435028

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.407

High

526462

HSP72
Heat shock protein SSA2

1

11

High-throughput

0.407

High

531700

RL4A
Large ribosomal subunit protein uL4A

1

4

High-throughput

0.407

High

544556

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.407

High

569762

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.407

High

592186

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

675925

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.407

High

689009

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.407

High

712546

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.407

High

741404

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.407

High

742826

HSP79
Heat shock protein homolog SSE2

1

15

High-throughput

0.407

High

753320

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.407

High

792656

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.407

High

792662

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.407

High

792677

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.407

High

792678

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

575330

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.269

Low

792665

IST1
Vacuolar protein sorting-associated protein IST1

1

0

High-throughput

0.269

Low

576962

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.265

Low

792663

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.265

Low

749662

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

792673

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.251

Low

792674

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.251

Low

792655

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

792670

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

792661

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

792671

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025