HitPredict

Interactor 1: CAZA2 (P47755)
F-actin-capping protein subunit alpha-2 (CapZ alpha-2)
Gene: CAPZA2

Interactor 2: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~F-actin_cap_A
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 286 Hs			1 376
+	Hs
		857093 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTZ_HUMAN (1-376): 0: 771: 100.00
+	Hs
		785519 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTY_HUMAN (1-376): 0: 728: 90.43
+	Hs
		785524 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTY_HUMAN (1-376): 0: 728: 90.43
+	Hs
		812976 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTB_HUMAN (7-376): 0: 580: 52.41
+	Hs
		812985 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTG_HUMAN (7-376): 0: 580: 52.67
+	Hs
		812987 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTC_HUMAN (5-376): 0: 576: 52.93
+	Hs
		812988 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTS_HUMAN (5-376): 0: 576: 52.39
+	Hs
		857090 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTB_HUMAN (7-376): 0: 580: 52.41
+	Hs
		857100 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTG_HUMAN (7-376): 0: 580: 52.67
+	Hs
		857101 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTC_HUMAN (5-376): 0: 576: 52.93
+	Dm
		862585 CAPZA_DROME (5-284): 3.22e-140: 397: 60.99		ACT3_DROME (7-376): 0: 574: 52.14