HitPredict

Interactor 1: CAZA2 (P47755)
F-actin-capping protein subunit alpha-2 (CapZ alpha-2)
Gene: CAPZA2

Interactor 2: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.759

Property	Details
Experiments	30890647, 26496610
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~F-actin_cap_A
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 286 Hs			1 377
+	Hs
		812976 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		812985 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTG_HUMAN (4-377): 0: 599: 94.39
+	Hs
		812988 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		ACTS_HUMAN (1-377): 0: 599: 98.94
+	Hs
		857090 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		857100 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTG_HUMAN (4-377): 0: 599: 94.39
+	Hs
		857101 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Dm
		862585 CAPZA_DROME (5-284): 3.22e-140: 397: 60.99		ACT3_DROME (1-377): 0: 595: 92.57