Protein: ATF4
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)

Gene: ATF4
Organism: Homo sapiens
Interactions: 105
UniProt ID: P18848

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

617207

CEBPG
CCAAT/enhancer-binding protein gamma

6

17

High-throughput

0.949

High

617125

ATF3
Cyclic AMP-dependent transcription factor ATF-3

3

16

Small-scale

0.879

High

429278

JUN
Transcription factor Jun

3

13

Small-scale

0.873

High

617224

NF2L2
Nuclear factor erythroid 2-related factor 2

3

9

Small-scale

0.866

High

370552

FOS
Protein c-Fos

3

12

Small-scale

0.840

High

617254

ZHANG
CREB/ATF bZIP transcription factor

3

0

Small-scale

0.826

High

617231

JDP2
Jun dimerization protein 2

2

14

High-throughput

0.783

High

282160

MAF
Transcription factor Maf

2

1

High-throughput

0.778

High

617204

CEBPA
CCAAT/enhancer-binding protein alpha

2

12

High-throughput

0.778

High

617225

BATF
Basic leucine zipper transcriptional factor ATF-like

2

12

High-throughput

0.778

High

583992

FOSL1
Fos-related antigen 1

2

14

Small-scale

0.768

High

606195

CEBPB
CCAAT/enhancer-binding protein beta

2

15

High-throughput

0.768

High

617205

CEBPD
CCAAT/enhancer-binding protein delta

2

16

Small-scale

0.768

High

603610

JUNB
Transcription factor JunB

2

8

High-throughput

0.767

High

617264

FBW1A
F-box/WD repeat-containing protein 1A

13

3

Small-scale

0.763

High

617241

TRIB3
Tribbles homolog 3

8

2

Small-scale

0.758

High

617195

ATF4
Cyclic AMP-dependent transcription factor ATF-4

2

0

Small-scale

0.738

High

617219

GPS2
G protein pathway suppressor 2

5

1

High-throughput

0.726

High

617217

EP300
Histone acetyltransferase p300

5

2

Small-scale

0.718

High

617244

CC106
Coiled-coil domain-containing protein 106

6

0

High-throughput

0.708

High

163894

NDC80
Kinetochore protein NDC80 homolog

5

0

High-throughput

0.691

High

617201

DDIT3
DNA damage-inducible transcript 3 protein

4

1

Small-scale

0.687

High

617262

FBW1B
F-box/WD repeat-containing protein 11

4

3

Small-scale

0.680

High

343733

LDOC1
Protein LDOC1

4

0

High-throughput

0.676

High

389789

TTHY
Transthyretin

3

1

High-throughput

0.666

High

617232

CBP
CREB-binding protein

3

3

Small-scale

0.658

High

230256

CREB3
Cyclic AMP-responsive element-binding protein 3

1

7

High-throughput

0.647

High

583447

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

High-throughput

0.647

High

617221

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

8

High-throughput

0.647

High

617223

CEBPE
CCAAT/enhancer-binding protein epsilon

1

15

High-throughput

0.647

High

617226

NFE2
Transcription factor NF-E2 45 kDa subunit

1

8

High-throughput

0.647

High

617230

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

3

High-throughput

0.647

High

617252

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

14

High-throughput

0.647

High

617266

NF2L3
Nuclear factor erythroid 2-related factor 3

1

5

High-throughput

0.647

High

617268

MAFB
Transcription factor MafB

1

8

High-throughput

0.647

High

617233

GOGA1
Golgin subfamily A member 1

3

0

High-throughput

0.646

High

617236

GCC1
GRIP and coiled-coil domain-containing protein 1

3

0

High-throughput

0.646

High

617249

EGLN3
Prolyl hydroxylase EGLN3

2

2

Small-scale

0.619

High

617076

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

4

Small-scale

0.618

High

617213

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.598

High

617253

DISC1
Disrupted in schizophrenia 1 protein

2

1

Small-scale

0.590

High

617215

REL
Proto-oncogene c-Rel

1

0

Small-scale

0.586

High

617242

HAUS7
HAUS augmin-like complex subunit 7

2

0

High-throughput

0.582

High

60488

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

0

High-throughput

0.580

High

617228

SAPC2
Suppressor APC domain-containing protein 2

2

0

High-throughput

0.580

High

617240

NP1L5
Nucleosome assembly protein 1-like 5

2

0

High-throughput

0.580

High

617245

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.580

High

617267

CEP83
Centrosomal protein of 83 kDa

2

0

High-throughput

0.580

High

617196

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.561

High

617239

EGLN2
Prolyl hydroxylase EGLN2

1

2

Small-scale

0.552

High

617258

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

4

Small-scale

0.552

High

343310

SNP29
Synaptosomal-associated protein 29

2

0

Small-scale

0.551

High

180699

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.541

High

617250

NEK6
Serine/threonine-protein kinase Nek6

1

0

Small-scale

0.526

High

161942

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

0

High-throughput

0.518

High

617198

LMNB1
Lamin-B1

1

0

High-throughput

0.518

High

617206

HXK3
Hexokinase-3

1

0

High-throughput

0.518

High

617238

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.518

High

617248

ASB7
Ankyrin repeat and SOCS box protein 7

1

0

High-throughput

0.518

High

617256

ZN226
Zinc finger protein 226

1

0

High-throughput

0.518

High

617263

TF2AY
TFIIA-alpha and beta-like factor

1

0

High-throughput

0.518

High

617259

ZN212
Zinc finger protein 212

1

1

Small-scale

0.508

High

617234

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.501

High

280498

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.493

High

617208

CASP6
Caspase-6

1

0

High-throughput

0.493

High

617255

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.493

High

617265

SHLB1
Endophilin-B1

1

0

High-throughput

0.493

High

617200

IKBA
NF-kappa-B inhibitor alpha

1

0

Small-scale

0.486

High

421467

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

569049

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.480

High

617197

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

617212

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.480

High

617251

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

617261

DNM3L
DNA

1

0

Small-scale

0.480

High

212632

DAPK3
Death-associated protein kinase 3

1

3

Small-scale

0.479

High

296851

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

4

Small-scale

0.479

High

612855

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

617222

ABRX2
BRISC complex subunit Abraxas 2

1

2

Small-scale

0.479

High

617260

DAPK2
Death-associated protein kinase 2

1

3

Small-scale

0.479

High

617199

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.460

High

617210

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.460

High

617216

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.460

High

617237

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.460

High

617243

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.460

High

469252

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

Small-scale

0.458

High

536467

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

617202

GBRB2
Gamma-aminobutyric acid receptor subunit beta-2

1

0

High-throughput

0.458

High

617203

SOX2
Transcription factor SOX-2

1

0

Small-scale

0.458

High

617209

IL2
Interleukin-2

1

0

Small-scale

0.458

High

617211

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

617214

PO5F1
POU domain, class 5, transcription factor 1

1

0

Small-scale

0.458

High

617246

EIF2A
Eukaryotic translation initiation factor 2A

1

0

Small-scale

0.458

High

617247

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

Small-scale

0.458

High

3429

A0A0S2Z507
Beta-transducin repeat containing isoform 3

1

3

High-throughput

0.417

High

85136

B7Z3H4
Beta-transducin repeat containing E3 ubiquitin protein ligase

1

3

High-throughput

0.417

High

617220

BFSP2
Phakinin

6

0

High-throughput

0.386

High

617227

TBC25
TBC1 domain family member 25

2

0

High-throughput

0.319

High

249376

MPZL2
Myelin protein zero-like protein 2

1

0

High-throughput

0.282

High

617235

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.282

High

617229

KTN1
Kinectin

1

0

High-throughput

0.269

Low

561887

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

617218

GOG8D
Putative golgin subfamily A member 8D

1

0

High-throughput

0.268

Low

617257

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low

215873

GRID2
Glutamate receptor ionotropic, delta-2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025