HitPredict

Interactor 1: CAZA2 (P47755)
F-actin-capping protein subunit alpha-2 (CapZ alpha-2)
Gene: CAPZA2

Interactor 2: CARL1 (Q5VZK9)
F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)
Gene: CARMIL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CARMIL_C~F-actin_cap_A
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 286 Hs			1 1371
+	Hs
		857144 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		CARL1_HUMAN (1-1371): 0: 740: 100.00
+	Hs
		813065 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		CARL2_HUMAN (1-1346): 1.46e-137: 459: 28.36
+	Mm
		812942 CAZA2_MOUSE (1-286): 4.17e-159: 445: 98.25		CARL2_MOUSE (1-1346): 3.05e-138: 458: 27.07
+	Hs
		857150 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		CARL2_HUMAN (1-1346): 1.46e-137: 459: 28.36
+	Mm
		812922 CAZA1_MOUSE (1-286): 5.06e-156: 438: 86.01		CARL2_MOUSE (1-1346): 3.05e-138: 458: 27.07
+	Dm
		90624 CAPZA_DROME (5-284): 3.22e-140: 397: 60.99		E1JGZ8_DROME (4-1261): 3.09e-151: 496: 33.53
+	Zm
		43607 B6U122_MAIZE (6-283): 4.32e-115: 335: 34.48		A0A1D6PPH2_MAIZE (449-903): 6.38e-24: 112: 12.94