HitPredict

Interactor 1: CAPZB (P47756)
F-actin-capping protein subunit beta (CapZ beta)
Gene: CAPZB

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~F_actin_cap_B
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0016020 - membrane GO:0070062 - extracellular exosome GO:0098685 - Schaffer collateral - CA1 synapse
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 272 Hs			1 375
+	Hs
		813521 CAPZB_HUMAN (1-272): 4.35e-177: 490: 100.00		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		813287 CAPZB_HUMAN (1-272): 4.35e-177: 490: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		813370 CAPZB_HUMAN (1-272): 4.35e-177: 490: 100.00		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Dm
		820547 CAPZB_DROME (1-269): 1.72e-166: 463: 81.78		ACT3_DROME (2-375): 0: 596: 94.92