HitPredict

Interactor 1: KCNJ4 (P48050)
Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)
Gene: KCNJ4

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

Property	Details
Experiments	10627592, 14960569, 11997254
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016323 - basolateral plasma membrane GO:0030165 - PDZ domain binding GO:0045211 - postsynaptic membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 724
+	Mm
		852403 KCNJ4_MOUSE (1-445): 0: 691: 96.86		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		942342 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		1143540 Q9QYK8_MOUSE (9-439): 0: 657: 97.45		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Rn
		677769 KCJ12_RAT (7-445): 0: 648: 63.55		DLG4_RAT (1-724): 0: 668: 99.86
+	Hs
		929762 KCNJ2_HUMAN (7-445): 0: 641: 60.46		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		816149 KCNJ4_HUMAN (1-445): 0: 690: 100.00		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		816147 KCNJ4_HUMAN (1-445): 0: 690: 100.00		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		159173 KCNJ4_HUMAN (1-445): 0: 690: 100.00		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		816150 KCNJ4_HUMAN (1-445): 0: 690: 100.00		DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09
+	Hs
		1049947 KCJ12_HUMAN (7-445): 0: 660: 63.86		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		1054729 KCJ12_HUMAN (7-445): 0: 660: 63.86		PALS2_HUMAN (2-203): 5.54e-21: 99.4: 14.42
+	Hs
		1021490 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		159210 KCJ12_HUMAN (7-445): 0: 660: 63.86		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		1054723 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09
+	Hs
		80982 KCJ18_HUMAN (7-445): 0: 654: 63.41		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Rn
		852397 KCJ12_RAT (7-445): 0: 648: 63.55		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Rn
		852398 KCJ12_RAT (7-445): 0: 648: 63.55		CSKP_RAT (6-200): 2.45e-19: 95.2: 14.80
+	Rn
		852400 KCJ12_RAT (7-445): 0: 648: 63.55		DLG2_RAT (225-474): 1.48e-18: 92.5: 21.09
+	Hs
		1054724 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Rn
		852399 KCJ12_RAT (7-445): 0: 648: 63.55		DLG3_RAT (221-548): 5.99e-15: 80.9: 18.55