HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	35140242, 21532573, 34591642
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0045597 - positive regulation of cell differentiation GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 1214
+	Hs
		818323 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Mm
		1142003 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		SMRC2_MOUSE (1-1203): 0: 957: 96.51
+	Mm
		956815 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		SMRC1_MOUSE (4-1028): 0: 952: 64.13
+	Mm
		818694 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		SMRC1_MOUSE (4-1028): 0: 952: 64.13
+	Hs
		818822 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		SMRC2_HUMAN (1-1203): 0: 992: 100.00
+	Hs
		818829 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		232040 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		818668 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		NCOR2_HUMAN (588-1208): 2.06e-32: 139: 14.22
+	Hs
		261435 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Mm
		101612 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		F8VQL9_MOUSE (588-1184): 5.51e-31: 135: 14.42
+	Mm
		1169785 HM20A_MOUSE (6-248): 5.08e-37: 137: 15.32		KDM1A_MOUSE (254-543): 9.03e-44: 174: 15.05
+	Hs
		232530 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		232072 SOX8_HUMAN (24-291): 8.81e-36: 135: 27.31		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Mm
		57186 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		CHD7_MOUSE (856-1214): 3.35e-12: 73.5: 11.26
+	Hs
		818266 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Hs
		727832 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		NCOR2_HUMAN (588-1208): 2.06e-32: 139: 14.22
+	Hs
		261421 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Hs
		261591 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Hs
		818819 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Hs
		1243843 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57