Protein: FKBP3
Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (FK506-binding nuclear protein) (FKBP-70) (Nucleolar proline isomerase) (Proline rotamase)

Gene: FKBP3, FPR3
Organism: Saccharomyces cerevisiae S288C
Interactions: 190
UniProt ID: P38911

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005527 - macrolide binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

743209

PP12
Serine/threonine-protein phosphatase PP1-2

5

3

Small-scale

0.919

High

392721

HSP82
ATP-dependent molecular chaperone HSP82

4

19

High-throughput

0.867

High

585933

CSK21
Casein kinase II subunit alpha

3

10

Small-scale

0.847

High

807151

FKBP4
FK506-binding protein 4

3

15

High-throughput

0.812

High

622949

CSK22
Casein kinase II subunit alpha'

2

11

Small-scale

0.755

High

807068

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

15

High-throughput

0.726

High

807173

NOP53
Ribosome biogenesis protein NOP53

5

1

Small-scale

0.702

High

709379

HRR25
Casein kinase I homolog HRR25

1

6

High-throughput

0.691

High

807104

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

9

High-throughput

0.691

High

807182

DBP10
ATP-dependent RNA helicase DBP10

4

4

High-throughput

0.680

High

579373

HSC82
ATP-dependent molecular chaperone HSC82

2

19

High-throughput

0.675

High

807094

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

1

High-throughput

0.670

High

523927

HSP71
Heat shock protein SSA1

4

16

High-throughput

0.666

High

807069

AURK
Aurora kinase

1

11

High-throughput

0.647

High

677201

SPB1
27S pre-rRNA

3

2

High-throughput

0.646

High

780263

EBP2
rRNA-processing protein EBP2

3

2

High-throughput

0.646

High

780676

RRP14
Ribosomal RNA-processing protein 14

3

1

High-throughput

0.646

High

807110

PESC
Pescadillo homolog

3

3

High-throughput

0.640

High

807128

NOG1
Nucleolar GTP-binding protein 1

3

5

Small-scale

0.640

High

807133

RRP17
Ribosomal RNA-processing protein 17

3

1

High-throughput

0.640

High

807120

H3
Histone H3

3

7

High-throughput

0.629

High

807124

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

10

High-throughput

0.618

High

807131

PKH1
Serine/threonine-protein kinase PKH1

1

11

High-throughput

0.618

High

807167

HRK1
Serine/threonine-protein kinase HRK1

1

5

High-throughput

0.618

High

364525

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.618

High

807181

SMT3
Ubiquitin-like protein SMT3

1

7

High-throughput

0.618

High

782333

RPF2
Ribosome biogenesis protein RPF2

2

4

High-throughput

0.611

High

807088

ULP2
Ubiquitin-like-specific protease 2

2

3

High-throughput

0.586

High

633160

MAK11
Protein MAK11

2

8

Small-scale

0.584

High

807090

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

807091

RLP7
Ribosome biogenesis protein RLP7

2

3

High-throughput

0.584

High

807115

NOP15
Ribosome biogenesis protein 15

2

5

High-throughput

0.584

High

807132

HAS1
ATP-dependent RNA helicase HAS1

2

9

High-throughput

0.584

High

807159

RLP24
Ribosome biogenesis protein RLP24

2

1

Small-scale

0.584

High

807163

BRX1
Ribosome biogenesis protein BRX1

2

13

High-throughput

0.576

High

381100

H2B1
Histone H2B.1

2

4

Small-scale

0.571

High

419732

H2A2
Histone H2A.2

2

3

High-throughput

0.571

High

670695

SIS1
Protein SIS1

2

3

High-throughput

0.571

High

679666

CDC48
Cell division control protein 48

2

9

Small-scale

0.571

High

805045

RPF1
Ribosome production factor 1

2

2

High-throughput

0.571

High

807083

ATAD2
ATPase histone chaperone YTA7

2

11

High-throughput

0.571

High

807137

RRB1
Ribosome assembly protein RRB1

2

4

High-throughput

0.571

High

807169

RRS1
Regulator of ribosome biosynthesis

2

1

High-throughput

0.571

High

807185

H2AZ
Histone H2A.Z

2

7

High-throughput

0.571

High

807084

PPAL
Low molecular weight phosphotyrosine protein phosphatase

1

0

Small-scale

0.554

High

526675

HSP72
Heat shock protein SSA2

2

16

High-throughput

0.552

High

807081

SSB2
Ribosome-associated molecular chaperone SSB2

2

16

High-throughput

0.552

High

544847

SSB1
Ribosome-associated molecular chaperone SSB1

1

16

High-throughput

0.536

High

807097

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

Small-scale

0.536

High

807108

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

2

High-throughput

0.536

High

807125

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

High-throughput

0.536

High

503040

RS22A
Small ribosomal subunit protein uS8A

2

3

High-throughput

0.533

High

807123

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.513

High

807135

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

807165

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

807111

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.489

High

807127

ULP1
Ubiquitin-like-specific protease 1

1

3

High-throughput

0.481

High

807166

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.480

High

149759

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

381515

H2B2
Histone H2B.2

1

4

High-throughput

0.479

High

435087

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

512436

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

534108

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

594363

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

644924

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

4

High-throughput

0.479

High

682276

SPB4
ATP-dependent rRNA helicase SPB4

1

8

High-throughput

0.479

High

689032

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

689452

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

707075

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

708733

TF3B
Transcription factor IIIB 70 kDa subunit

1

5

High-throughput

0.479

High

709747

BMH1
Protein BMH1

1

3

High-throughput

0.479

High

734976

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

746625

DRS1
ATP-dependent RNA helicase DRS1

1

6

High-throughput

0.479

High

750081

MRT4
Ribosome assembly factor MRT4

1

2

High-throughput

0.479

High

763070

RRP1
Ribosomal RNA-processing protein 1

1

2

High-throughput

0.479

High

792040

GBLP
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.479

High

795817

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

798215

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

803860

CIC1
Proteasome-interacting protein CIC1

1

2

High-throughput

0.479

High

804609

SSF1
Ribosome biogenesis protein SSF1

1

1

High-throughput

0.479

High

807075

NOC2
Nucleolar complex protein 2

1

3

High-throughput

0.479

High

807077

NOP16
Nucleolar protein 16

1

1

High-throughput

0.479

High

807078

NUG1
Nuclear GTP-binding protein NUG1

1

2

High-throughput

0.479

High

807080

NSA2
Ribosome biogenesis protein NSA2

1

2

High-throughput

0.479

High

807092

NOP2
25S rRNA

1

5

High-throughput

0.479

High

807093

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.479

High

807105

MOG1
Nuclear import protein MOG1

1

3

High-throughput

0.479

High

807107

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.479

High

807109

NSA1
Ribosome biogenesis protein NSA1

1

1

High-throughput

0.479

High

807112

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

High-throughput

0.479

High

807113

NOP13
Nucleolar protein 13

1

1

High-throughput

0.479

High

807116

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

807119

ORC1
Origin recognition complex subunit 1

1

4

High-throughput

0.479

High

807130

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

807136

DHR1
Probable ATP-dependent RNA helicase DHR1

1

4

High-throughput

0.479

High

807141

PUF6
Pumilio homology domain family member 6

1

3

High-throughput

0.479

High

807144

ERB1
Ribosome biogenesis protein ERB1

1

9

High-throughput

0.479

High

807146

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.479

High

807147

HRQ1
ATP-dependent helicase HRQ1

1

2

Small-scale

0.479

High

807149

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

807150

PDP3
NuA3 HAT complex component PDP3

1

3

High-throughput

0.479

High

807152

JIP5
WD repeat-containing protein JIP5

1

4

High-throughput

0.479

High

807153

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

807154

RRP15
Ribosomal RNA-processing protein 15

1

1

High-throughput

0.479

High

807155

NOC4
Nucleolar complex protein 4

1

6

High-throughput

0.479

High

807158

NOC3
Nucleolar complex-associated protein 3

1

4

High-throughput

0.479

High

807162

NOP12
Nucleolar protein 12

1

6

High-throughput

0.479

High

807164

SGO1
Shugoshin

1

1

High-throughput

0.479

High

807170

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

807171

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.479

High

807172

YTM1
Ribosome biogenesis protein YTM1

1

11

High-throughput

0.479

High

807176

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

807178

MAK21
Ribosome biogenesis protein MAK21

1

6

High-throughput

0.479

High

807184

IF6
Eukaryotic translation initiation factor 6

1

3

High-throughput

0.479

High

645408

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

758212

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.458

High

807070

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

807174

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

807177

YRA1
RNA annealing protein YRA1

1

0

Small-scale

0.458

High

668428

PTP1
Tyrosine-protein phosphatase 1

1

2

Small-scale

0.457

High

807114

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.457

High

382098

H4
Histone H4

1

5

High-throughput

0.445

High

444851

SIR3
Regulatory protein SIR3

1

2

High-throughput

0.445

High

534263

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

Small-scale

0.445

High

645733

HSP74
Heat shock protein SSA4

1

16

High-throughput

0.445

High

651935

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

4

High-throughput

0.445

High

675995

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

694544

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.445

High

741568

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

781742

SET3
SET domain-containing protein 3

1

2

High-throughput

0.445

High

805936

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

1

High-throughput

0.445

High

807079

UTP7
U3 small nucleolar RNA-associated protein 7

1

6

High-throughput

0.445

High

807096

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.445

High

807099

YPP1
Cargo-transport protein YPP1

1

1

High-throughput

0.445

High

807101

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

3

High-throughput

0.445

High

807102

NET1
Nucleolar protein NET1

1

1

High-throughput

0.445

High

807103

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.445

High

807122

SEN1
Helicase SEN1

1

3

Small-scale

0.445

High

807129

HOS3
Histone deacetylase HOS3

1

4

High-throughput

0.445

High

807145

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.445

High

807157

RIX7
Ribosome biogenesis ATPase RIX7

1

9

High-throughput

0.445

High

807161

BUD20
Bud site selection protein 20

1

1

High-throughput

0.445

High

807179

RLM1
Transcription factor RLM1

1

1

High-throughput

0.445

High

410127

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

430846

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

Small-scale

0.437

High

433637

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

455060

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

513006

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

514636

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

753366

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

802170

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

807073

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.437

High

807074

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

807086

MLP2
Protein MLP2

1

5

High-throughput

0.437

High

807117

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.437

High

807121

NUM1
Nuclear migration protein NUM1

1

7

High-throughput

0.437

High

807126

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

807156

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

807168

RS10A
Small ribosomal subunit protein eS10A

1

7

High-throughput

0.437

High

807186

RS22B
Small ribosomal subunit protein uS8B

1

3

High-throughput

0.437

High

649960

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

807085

PTPA1
Serine/threonine-protein phosphatase 2A activator 1

1

0

High-throughput

0.426

High

807095

ECO1
N-acetyltransferase ECO1

1

0

High-throughput

0.426

High

807134

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.426

High

807140

BUD22
Bud site selection protein 22

1

0

High-throughput

0.426

High

807143

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.426

High

807160

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

752251

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.407

High

790358

STT4
Phosphatidylinositol 4-kinase STT4

1

4

High-throughput

0.407

High

807082

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

1

Small-scale

0.407

High

807098

STU2
Protein STU2

1

1

High-throughput

0.407

High

807106

HLJ1
Protein HLJ1

1

4

High-throughput

0.407

High

807118

HDA1
Histone deacetylase HDA1

1

3

High-throughput

0.407

High

807089

INP51
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51

1

0

High-throughput

0.279

Low

807148

RGC1
Regulator of the glycerol channel 1

1

0

High-throughput

0.279

Low

504209

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

746003

VATL2
V-type proton ATPase subunit c'

1

0

High-throughput

0.249

Low

747356

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

807076

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.249

Low

807087

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

807175

APC9
Anaphase-promoting complex subunit 9

1

0

High-throughput

0.249

Low

807183

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.249

Low

807071

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.232

Low

807072

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

807100

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

807138

UBX2
UBX domain-containing protein 2

1

0

Small-scale

0.232

Low

807139

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.232

Low

807142

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low

807180

CRM2
Homeostatic regulator of DAG

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025