HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28794006, 23667531
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 3159
+	Hs
		818836 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229339 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Mm
		1142014 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		SMCA5_MOUSE (964-1548): 0: 630: 21.32
+	Hs
		658738 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		818102 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		818484 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Mm
		57186 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		CHD7_MOUSE (2260-2812): 3.28e-15: 85.3: 8.12
+	Hs
		818550 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		817809 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		817810 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Mm
		818702 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57
+	Hs
		727814 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		818841 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		1332326 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		818784 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		881831 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		818785 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		846868 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Mm
		1111947 NSD2_MOUSE (10-255): 7.97e-34: 133: 11.16		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57
+	Hs
		846730 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65