HitPredict

Interactor 1: RAC2 (P48554)
Ras-related protein Rac2
Gene: RAC2

Interactor 2: SPRI (Q8MQW8)
Protein sprint (SH2 poly-proline-containing Ras-interactor protein)
Gene: SPRI

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~VPS9
Common GO terms	GO:0007165 - signal transduction GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Dm			1 1789
+	Dm
		776893 RAC1_DROME (1-192): 2.59e-81: 241: 93.23		SPRI_DROME (1-1789): 0: 1399: 100.00
+	Ce
		104435 RAC1_CAEEL (1-192): 1.93e-82: 244: 79.69		G5EBS9_CAEEL (967-1786): 4.8e-170: 543: 22.87
+	Hs
		412123 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		FYN_HUMAN (317-630): 1.18e-53: 199: 14.78
+	Hs
		522888 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		SRC_HUMAN (330-579): 1.03e-53: 199: 16.54
+	Hs
		411980 RAC2_HUMAN (1-192): 1.07e-80: 239: 88.02		FYN_HUMAN (317-630): 1.18e-53: 199: 14.78
+	Hs
		412113 CDC42_HUMAN (1-192): 6.35e-77: 230: 67.71		FYN_HUMAN (317-630): 1.18e-53: 199: 14.78
+	Hs
		433244 RHOQ_HUMAN (4-179): 1.12e-84: 250: 66.48		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433314 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433239 RAC2_HUMAN (1-192): 1.07e-80: 239: 88.02		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433475 RHOJ_HUMAN (2-190): 3.72e-79: 236: 59.79		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		433322 RHOG_HUMAN (1-192): 3.93e-77: 230: 67.71		YES_HUMAN (336-579): 7.94e-47: 179: 14.68
+	Hs
		564569 RHOQ_HUMAN (4-179): 1.12e-84: 250: 66.48		TENS3_HUMAN (453-605): 1.02e-32: 141: 20.33
+	Hs
		925353 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		TENS3_HUMAN (453-605): 1.02e-32: 141: 20.33
+	Hs
		545440 RAC2_HUMAN (1-192): 1.07e-80: 239: 88.02		TENS3_HUMAN (453-605): 1.02e-32: 141: 20.33
+	Hs
		297823 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Hs
		297812 RAC2_HUMAN (1-192): 1.07e-80: 239: 88.02		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Ce
		105104 RAC1_CAEEL (1-192): 1.93e-82: 244: 79.69		G5ECF0_CAEEL (333-646): 5.58e-23: 109: 22.74
+	Hs
		297840 RHOJ_HUMAN (2-190): 3.72e-79: 236: 59.79		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Hs
		297827 RHOG_HUMAN (1-192): 3.93e-77: 230: 67.71		K0754_HUMAN (560-1147): 7.49e-25: 116: 15.24
+	Hs
		73275 B4E1U9_HUMAN (1-192): 1.77e-85: 253: 54.85		RIN3_HUMAN (761-1089): 6.26e-09: 63.2: 10.30