HitPredict

Interactor 1: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Interactor 2: MKKS (Q9NPJ1)
Molecular chaperone MKKS (Bardet-Biedl syndrome 6 protein) (McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin)
Gene: MKKS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	20080638
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~Cpn60_TCP1
Common GO terms	GO:0005524 - ATP binding GO:0005813 - centrosome GO:0005829 - cytosol GO:0006457 - protein folding GO:0051082 - unfolded protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 541 Hs			1 570
+	Hs
		821381 TCPE_HUMAN (1-541): 0: 635: 100.00		TCPH_HUMAN (9-531): 2.65e-167: 488: 16.21
+	Hs
		821117 TCPE_HUMAN (1-541): 0: 635: 100.00		TCPG_HUMAN (4-519): 7.61e-164: 479: 19.05
+	Bt
		94406 F1MWD3_BOVIN (1-541): 0: 630: 97.23		TCPH_BOVIN (9-529): 1.43e-165: 483: 15.91
+	Hs
		821127 TCPE_HUMAN (1-541): 0: 635: 100.00		TCPD_HUMAN (19-515): 4.97e-153: 451: 18.65
+	Mm
		945916 TCPH_MOUSE (12-539): 0: 575: 29.46		TCPH_MOUSE (9-536): 6.93e-172: 499: 16.19
+	Hs
		826843 TCPG_HUMAN (14-540): 0: 572: 33.15		TCPH_HUMAN (9-531): 2.65e-167: 488: 16.21
+	Ph
		223354 THS_PYRHO (13-536): 0: 570: 42.59		THS_PYRHO (6-521): 4.17e-160: 469: 17.86
+	Sc
		772895 TCPE_YEAST (3-540): 0: 582: 59.89		TCPH_YEAST (1-539): 7.72e-155: 456: 15.71
+	Hs
		826901 TCPG_HUMAN (14-540): 0: 572: 33.15		MKKS_HUMAN (1-570): 9.88e-158: 464: 100.00
+	Dm
		1180663 Q7KKI0_DROME (5-533): 0: 582: 71.46		Q9VHL2_DROME (6-523): 2.06e-150: 445: 15.63
+	Hs
		826574 TCPG_HUMAN (14-540): 0: 572: 33.15		TCPD_HUMAN (19-515): 4.97e-153: 451: 18.65
+	Dm
		820635 Q7KKI0_DROME (5-533): 0: 582: 71.46		TCPG_DROME (6-490): 1.46e-136: 409: 18.32
+	Dm
		820672 Q9VHL2_DROME (14-541): 0: 577: 28.14		TCPG_DROME (6-490): 1.46e-136: 409: 18.32
+	Sc
		519953 TCPE_YEAST (3-540): 0: 582: 59.89		TCPA_YEAST (15-476): 3.58e-129: 391: 20.33
+	Sc
		760745 TCPE_YEAST (3-540): 0: 582: 59.89		TCPG_YEAST (24-490): 1.77e-120: 367: 16.70
+	Dm
		1180665 Q7KKI0_DROME (5-533): 0: 582: 71.46		Q9VK69_DROME (13-479): 2.08e-107: 334: 18.39
+	Dm
		1367297 Q9VHL2_DROME (14-541): 0: 577: 28.14		Q9VK69_DROME (13-479): 2.08e-107: 334: 18.39
+	Sc
		760873 TCPE_YEAST (3-540): 0: 582: 59.89		TCPD_YEAST (13-476): 6.07e-105: 327: 19.26