HitPredict

Interactor 1: FNTA (P49354)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)
Gene: FNTA

Interactor 2: FNTB (P49356)
Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta)
Gene: FNTB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.979

The method score is based on:

Property Details
Experiments 26186194, 28514442, 24981860, 33961781, 32296183, 11687658, 12036349, 15248757, unassigned1304, 12825937, 15170324
Identification Methods affinity chromatography technology, two hybrid, x-ray crystallography, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation, mammalian protein protein interaction trap, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PPTA~Prenyltrans
Common GO terms GO:0004660 - protein farnesyltransferase activity
GO:0005829 - cytosol
GO:0005875 - microtubule associated complex
GO:0005965 - protein farnesyltransferase complex
GO:0018343 - protein farnesylation
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 379
Hs

1 437
+ Rn
+ Dm
+ Hs
+ Ce
+ Rn
+ At
+ Sp
+ Sc
+ Ce
+ At
+ Hs
+ Rn
+ Hs
+ Sc
+ Dm
+ Sp
+ Sc
+ Dm

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Last updated: 15 Jul 2024