Protein: RIGI
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)

Gene: RIGI
Organism: Homo sapiens
Interactions: 122
UniProt ID: O95786

Gene Ontology (top 5):
GO:0002230 - positive regulation of defense response to virus by host
GO:0002735 - positive regulation of myeloid dendritic cell cytokine production
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003690 - double-stranded DNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

345085

MAVS
Mitochondrial antiviral-signaling protein

54

12

Small-scale

0.996

High

345070

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

37

20

Small-scale

0.994

High

345031

RIGI
Antiviral innate immune response receptor RIG-I

10

17

Small-scale

0.974

High

345090

RN135
E3 ubiquitin-protein ligase RNF135

7

19

Small-scale

0.973

High

345038

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

12

Small-scale

0.899

High

345034

ISG15
Ubiquitin-like protein ISG15

3

17

Small-scale

0.839

High

345101

DHX58
ATP-dependent RNA helicase DHX58

3

18

Small-scale

0.827

High

286842

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

2

20

Small-scale

0.802

High

181964

UBD
Ubiquitin D

2

18

Small-scale

0.754

High

238844

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

13

Small-scale

0.724

High

345109

TRIM6
Tripartite motif-containing protein 6

1

9

Small-scale

0.724

High

345103

RN125
E3 ubiquitin-protein ligase RNF125

4

20

Small-scale

0.704

High

345067

SQSTM
Sequestosome-1

5

12

Small-scale

0.702

High

345124

RAI14
Ankycorbin

1

9

High-throughput

0.691

High

166728

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

5

Small-scale

0.665

High

345089

STING
Stimulator of interferon genes protein

3

5

Small-scale

0.657

High

345072

IRF3
Interferon regulatory factor 3

3

7

Small-scale

0.650

High

345081

TRI65
E3 ubiquitin-protein ligase TRIM65

1

18

Small-scale

0.647

High

345128

TBK1
Serine/threonine-protein kinase TBK1

3

15

Small-scale

0.640

High

345104

WRIP1
ATPase WRNIP1

2

3

High-throughput

0.639

High

141249

DDX3X
ATP-dependent RNA helicase DDX3X

1

17

Small-scale

0.618

High

240396

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.618

High

345037

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

12

Small-scale

0.618

High

345042

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

13

Small-scale

0.618

High

345068

TRI14
Tripartite motif-containing protein 14

1

20

High-throughput

0.618

High

345071

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

8

Small-scale

0.618

High

345083

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

345098

FBXW7
F-box/WD repeat-containing protein 7

1

20

Small-scale

0.618

High

345108

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

9

Small-scale

0.618

High

345112

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

20

Small-scale

0.618

High

345123

PD1L1
Programmed cell death 1 ligand 1

1

2

Small-scale

0.618

High

345117

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

4

Small-scale

0.612

High

49986

IRGM
Immunity-related GTPase family M protein

2

0

Small-scale

0.598

High

345065

G3BP1
Ras GTPase-activating protein-binding protein 1

2

15

Small-scale

0.584

High

345111

ATG5
Autophagy protein 5

1

1

Small-scale

0.569

High

345035

KPCB
Protein kinase C beta type

1

8

Small-scale

0.561

High

345041

KPCA
Protein kinase C alpha type

1

8

Small-scale

0.561

High

345080

TRI40
E3 ubiquitin ligase TRIM40

1

18

Small-scale

0.561

High

345091

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.561

High

345115

RN122
RING finger protein 122

1

5

Small-scale

0.561

High

345132

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

Small-scale

0.561

High

345135

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

14

Small-scale

0.561

High

345093

LRC25
Leucine-rich repeat-containing protein 25

2

0

Small-scale

0.559

High

345082

WDR82
WD repeat-containing protein 82

1

20

Small-scale

0.553

High

345134

SNX5
Sorting nexin-5

1

1

Small-scale

0.552

High

345084

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

8

Small-scale

0.546

High

345064

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.536

High

345125

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.536

High

345039

IRF1
Interferon regulatory factor 1

1

7

Small-scale

0.534

High

345069

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

10

Small-scale

0.515

High

345116

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

9

Small-scale

0.515

High

345122

NOP53
Ribosome biogenesis protein NOP53

1

1

Small-scale

0.515

High

345130

ASC
Apoptosis-associated speck-like protein containing a CARD

1

4

Small-scale

0.515

High

345033

KPCG
Protein kinase C gamma type

1

11

Small-scale

0.501

High

345050

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

3

Small-scale

0.501

High

345052

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

3

Small-scale

0.501

High

345053

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

4

Small-scale

0.501

High

345056

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

3

Small-scale

0.501

High

317600

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.500

High

215769

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

0

Small-scale

0.480

High

50381

MEX3A
RNA-binding protein MEX3A

1

20

Small-scale

0.479

High

143515

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

10

High-throughput

0.479

High

175960

N4BP3
NEDD4-binding protein 3

1

7

Small-scale

0.479

High

246369

KDM1A
Lysine-specific histone demethylase 1A

1

7

Small-scale

0.479

High

345036

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

Small-scale

0.479

High

345040

SRC
Proto-oncogene tyrosine-protein kinase Src

1

8

Small-scale

0.479

High

345043

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

9

Small-scale

0.479

High

345044

CBL
E3 ubiquitin-protein ligase CBL

1

14

Small-scale

0.479

High

345047

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

345048

IFI27
Interferon alpha-inducible protein 27, mitochondrial

1

2

Small-scale

0.479

High

345049

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.479

High

345051

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

13

Small-scale

0.479

High

345054

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.479

High

345055

1433E
14-3-3 protein epsilon

1

4

Small-scale

0.479

High

345057

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

11

Small-scale

0.479

High

345058

IN35
Interferon-induced 35 kDa protein

1

1

Small-scale

0.479

High

345059

TIAR
Nucleolysin TIAR

1

16

Small-scale

0.479

High

345060

TF65
Transcription factor p65

1

9

Small-scale

0.479

High

345061

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

6

Small-scale

0.479

High

345062

TRI32
E3 ubiquitin-protein ligase TRIM32

1

15

Small-scale

0.479

High

345063

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

15

Small-scale

0.479

High

345066

BIRC2
Baculoviral IAP repeat-containing protein 2

1

14

Small-scale

0.479

High

345073

CASP8
Caspase-8

1

8

Small-scale

0.479

High

345074

PCBP1
Poly(rC)-binding protein 1

1

20

Small-scale

0.479

High

345075

PCBP2
Poly(rC)-binding protein 2

1

20

Small-scale

0.479

High

345076

ELAV1
ELAV-like protein 1

1

13

Small-scale

0.479

High

345078

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

13

Small-scale

0.479

High

345079

Z518A
Zinc finger protein 518A

1

4

High-throughput

0.479

High

345086

ZN598
E3 ubiquitin-protein ligase ZNF598

1

6

Small-scale

0.479

High

345087

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

11

High-throughput

0.479

High

345088

NLRC5
Protein NLRC5

1

8

Small-scale

0.479

High

345092

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

13

Small-scale

0.479

High

345094

FA98A
Protein FAM98A

1

2

High-throughput

0.479

High

345096

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

9

Small-scale

0.479

High

345097

IRF7
Interferon regulatory factor 7

1

7

Small-scale

0.479

High

345099

RNF34
E3 ubiquitin-protein ligase RNF34

1

12

Small-scale

0.479

High

345100

LRC59
Leucine-rich repeat-containing protein 59

1

6

Small-scale

0.479

High

345102

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.479

High

345105

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

14

Small-scale

0.479

High

345106

RNF5
E3 ubiquitin-protein ligase RNF5

1

15

Small-scale

0.479

High

345107

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

12

Small-scale

0.479

High

345110

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

19

Small-scale

0.479

High

345113

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

345114

AZI2
5-azacytidine-induced protein 2

1

1

Small-scale

0.479

High

345118

MDN1
Midasin

1

8

High-throughput

0.479

High

345119

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

9

Small-scale

0.479

High

345120

RN19A
E3 ubiquitin-protein ligase RNF19A

1

9

Small-scale

0.479

High

345126

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.479

High

345129

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

Small-scale

0.479

High

345131

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.479

High

345133

ARI1
E3 ubiquitin-protein ligase ARIH1

1

19

Small-scale

0.479

High

345136

NEMO
NF-kappa-B essential modulator

1

7

Small-scale

0.479

High

222339

TSN6
Tetraspanin-6

1

6

Small-scale

0.470

High

345032

MBP
Myelin basic protein

1

0

Small-scale

0.458

High

345121

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

345045

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

High-throughput

0.445

High

328835

RTN3
Reticulon-3

1

4

Small-scale

0.437

High

345127

KLOT
Klotho

1

1

Small-scale

0.437

High

345095

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

345046

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

Small-scale

0.249

Low

345077

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025