Protein: LIMK1
LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)

Gene: LIMK1
Organism: Homo sapiens
Interactions: 94
UniProt ID: P53667

Gene Ontology (top 5):
GO:0001673 - male germ cell nucleus
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618026

COF1
Cofilin-1

12

4

Small-scale

0.979

High

863756

LIMK2
LIM domain kinase 2

3

18

Small-scale

0.853

High

863755

LIMK1
LIM domain kinase 1

2

18

Small-scale

0.812

High

863758

HUNK
Hormonally up-regulated neu tumor-associated kinase

2

11

Small-scale

0.793

High

863766

PAK1
Serine/threonine-protein kinase PAK 1

1

20

Small-scale

0.785

High

863760

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.783

High

824620

MAPK2
MAP kinase-activated protein kinase 2

1

20

Small-scale

0.735

High

863767

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.735

High

863772

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.735

High

863796

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.735

High

863770

BMPR2
Bone morphogenetic protein receptor type-2

1

18

Small-scale

0.713

High

234492

DSCAM
Cell adhesion molecule DSCAM

1

6

High-throughput

0.698

High

330924

PAK4
Serine/threonine-protein kinase PAK 4

1

20

Small-scale

0.692

High

863808

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

20

High-throughput

0.692

High

51060

SPD2B
SH3 and PX domain-containing protein 2B

1

20

High-throughput

0.691

High

412099

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.691

High

488067

RRAS
Ras-related protein R-Ras

1

20

High-throughput

0.691

High

542842

BRAF
Serine/threonine-protein kinase B-raf

1

14

High-throughput

0.691

High

863795

ERBIN
Erbin

1

20

High-throughput

0.691

High

863802

OSBL5
Oxysterol-binding protein-related protein 5

1

7

High-throughput

0.691

High

325668

LATS1
Serine/threonine-protein kinase LATS1

1

20

Small-scale

0.690

High

568595

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

17

Small-scale

0.647

High

863804

PAK6
Serine/threonine-protein kinase PAK 6

1

20

Small-scale

0.647

High

801040

KI67
Proliferation marker protein Ki-67

2

9

High-throughput

0.628

High

863786

RXFP2
Relaxin receptor 2

1

18

High-throughput

0.618

High

118713

AIP
AH receptor-interacting protein

1

20

High-throughput

0.618

High

683916

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

863759

1433E
14-3-3 protein epsilon

1

10

High-throughput

0.618

High

863782

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

863787

SSH1
Protein phosphatase Slingshot homolog 1

1

19

Small-scale

0.615

High

863764

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

6

Small-scale

0.573

High

685856

ARRB2
Beta-arrestin-2

1

3

Small-scale

0.561

High

827133

ARRB1
Beta-arrestin-1

1

3

Small-scale

0.561

High

836897

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

3

Small-scale

0.552

High

50120

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.536

High

62527

RFOX3
RNA binding protein fox-1 homolog 3

1

8

High-throughput

0.536

High

518618

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

3

High-throughput

0.536

High

596038

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

3

High-throughput

0.536

High

604134

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

1

High-throughput

0.536

High

653209

PYR1
Multifunctional protein CAD

1

9

High-throughput

0.536

High

676843

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.536

High

843452

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

3

High-throughput

0.536

High

857953

NUP98
Nuclear pore complex protein Nup98-Nup96

1

6

High-throughput

0.536

High

863757

ITA1
Integrin alpha-1

1

5

High-throughput

0.536

High

863762

BORG5
Cdc42 effector protein 1

1

1

High-throughput

0.536

High

863771

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.536

High

863773

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.536

High

863775

AGK
Acylglycerol kinase, mitochondrial

1

2

High-throughput

0.536

High

863783

SEP14
Septin-14

1

16

High-throughput

0.536

High

863784

LONP2
Lon protease homolog 2, peroxisomal

1

7

High-throughput

0.536

High

863789

RAD54
DNA repair and recombination protein RAD54-like

1

9

High-throughput

0.536

High

863790

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.536

High

863791

BAD
Bcl2-associated agonist of cell death

1

3

High-throughput

0.536

High

863793

S35E1
Solute carrier family 35 member E1

1

1

High-throughput

0.536

High

863794

RBM14
RNA-binding protein 14

1

12

High-throughput

0.536

High

863797

MMS19
MMS19 nucleotide excision repair protein homolog

1

4

High-throughput

0.536

High

863798

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

3

High-throughput

0.536

High

863799

LGMN
Legumain

1

1

High-throughput

0.536

High

863800

METH
Methionine synthase

1

1

High-throughput

0.536

High

863809

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.536

High

181401

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

267636

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.513

High

863761

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.513

High

863769

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

863801

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.513

High

863805

RTEL1
Regulator of telomere elongation helicase 1

1

0

High-throughput

0.513

High

863806

UXT
Protein UXT

1

0

High-throughput

0.513

High

362070

MBP
Myelin basic protein

1

2

Small-scale

0.501

High

394388

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

863765

H11
Histone H1.1

1

5

Small-scale

0.501

High

863807

FBX7
F-box only protein 7

1

8

High-throughput

0.501

High

778084

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

12

High-throughput

0.489

High

863779

MIIP
Migration and invasion-inhibitory protein

1

1

High-throughput

0.489

High

863781

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.489

High

863792

ATPMK
ATP synthase membrane subunit K, mitochondrial

1

2

High-throughput

0.489

High

863803

GHC1
Mitochondrial glutamate carrier 1

1

15

High-throughput

0.489

High

226951

PRKN
E3 ubiquitin-protein ligase parkin

1

12

Small-scale

0.479

High

431683

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

438022

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

575346

EGR1
Early growth response protein 1

1

5

High-throughput

0.479

High

714150

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

838512

MMP14
Matrix metalloproteinase-14

1

6

Small-scale

0.479

High

863763

KIF23
Kinesin-like protein KIF23

1

4

Small-scale

0.479

High

863768

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.479

High

863774

Q4LE69
1-phosphatidylinositol 4-kinase

1

8

High-throughput

0.479

High

863778

DCAF6
DDB1- and CUL4-associated factor 6

1

13

High-throughput

0.479

High

863785

SSH3
Protein phosphatase Slingshot homolog 3

1

18

Small-scale

0.479

High

66269

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

787636

PI4KA
Phosphatidylinositol 4-kinase alpha

1

8

High-throughput

0.445

High

863776

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.445

High

863777

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.445

High

863788

CV015
Uncharacterized protein C22orf15

3

0

High-throughput

0.346

High

863780

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024