HitPredict

Interactor 1: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	32445435, 19306926, 19782076
Identification Methods	affinity chromatography technology, unspecified method, peptide array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 1374
+	Hs
		686043 ARRB2_HUMAN (1-407): 0: 626: 76.15		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		685940 ARRB2_HUMAN (1-407): 0: 626: 76.15		KCC2D_HUMAN (678-995): 1.4e-97: 324: 26.53
+	Dm
		580710 ARRB_DROME (5-403): 0: 517: 42.65		KCC2A_DROME (678-1086): 2.78e-112: 365: 21.98
+	Hs
		827185 ARRB1_HUMAN (1-418): 0: 716: 100.00		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		681739 ARRB1_HUMAN (1-418): 0: 716: 100.00		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Mm
		682118 ARRB1_MOUSE (1-418): 0: 703: 98.57		AKT1_MOUSE (438-615): 2e-25: 113: 14.14
+	Hs
		685929 ARRB2_HUMAN (1-407): 0: 626: 76.15		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		681683 ARRB2_HUMAN (1-407): 0: 626: 76.15		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Hs
		682136 ARRB2_HUMAN (1-407): 0: 626: 76.15		AKT2_HUMAN (438-620): 9.26e-25: 111: 13.24
+	Mm
		682122 ARRB2_MOUSE (1-407): 0: 615: 75.00		AKT1_MOUSE (438-615): 2e-25: 113: 14.14