HitPredict

Interactor 1: AMPH (P49418)
Amphiphysin
Gene: AMPH

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	15834155, 16696976, 10542231
Identification Methods	pull down, peptide array, surface plasmon resonance
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 870
+	Mm
		760477 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Rn
		139974 AMPH_RAT (1-695): 6.91e-115: 362: 84.75		DYN2_RAT (1-870): 0: 1053: 98.05
+	Hs
		827736 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		827766 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Mm
		760459 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Mm
		1186718 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		DYN3_MOUSE (1-870): 0: 992: 77.90
+	Rn
		139973 AMPH_RAT (1-695): 6.91e-115: 362: 84.75		DYN1_RAT (1-846): 0: 994: 78.57
+	Hs
		840739 DNMBP_HUMAN (12-536): 5.06e-55: 206: 18.97		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		983387 DNMBP_HUMAN (12-536): 5.06e-55: 206: 18.97		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		1167839 DNMBP_HUMAN (12-536): 5.06e-55: 206: 18.97		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Mm
		139029 BIN1_MOUSE (372-695): 1.35e-34: 141: 23.15		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		131222 BIN1_HUMAN (375-694): 1.37e-32: 135: 23.44		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		139028 BIN1_MOUSE (372-695): 1.35e-34: 141: 23.15		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Hs
		131238 BIN1_HUMAN (375-694): 1.37e-32: 135: 23.44		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Mm
		139042 BIN1_MOUSE (372-695): 1.35e-34: 141: 23.15		DYN3_MOUSE (1-870): 0: 992: 77.90
+	Rn
		139987 BIN1_RAT (372-695): 8.26e-34: 139: 23.15		DYN1_RAT (1-846): 0: 994: 78.57
+	Hs
		983422 CABIN_HUMAN (291-589): 2.25e-12: 72.8: 12.87		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Ce
		105220 G5ECK4_CAEEL (12-625): 5.15e-33: 138: 15.04		DYN1_CAEEL (3-823): 0: 899: 61.86
+	Sc
		599466 RV167_YEAST (11-424): 3.83e-41: 158: 15.63		VPS1_YEAST (7-739): 0: 693: 37.39