HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 3969
+	Hs
		934681 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		828421 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		935368 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		934804 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1080038 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		935204 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		203659 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Hs
		203711 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Hs
		935237 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SUV92_HUMAN (3577-3969): 7.13e-82: 278: 18.97
+	Hs
		935276 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		ASH1L_HUMAN (3266-3968): 1.46e-72: 275: 14.78
+	At
		886462 H33_ARATH (5-134): 3.87e-52: 163: 51.15		SUVH4_ARATH (3639-3968): 3.43e-77: 272: 19.90
+	Hs
		935374 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		331748 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		331780 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		828367 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		935205 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		165661 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		935004 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		935150 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18
+	Hs
		152625 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47