Protein: RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

Gene: RPRD2
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q5VT52

Gene Ontology (top 5):
GO:0000993 - RNA polymerase II complex binding
GO:0005654 - nucleoplasm
GO:0031124 - mRNA 3'-end processing
GO:0097550 - transcription preinitiation complex
GO:0099122 - RNA polymerase II C-terminal domain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1137958

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

4

15

High-throughput

0.903

High

913902

RPB7
DNA-directed RNA polymerase II subunit RPB7

5

5

High-throughput

0.718

High

1137943

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

13

High-throughput

0.691

High

1137964

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

3

High-throughput

0.675

High

123970

SPT5H
Transcription elongation factor SPT5

3

8

High-throughput

0.667

High

504224

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.628

High

638308

RBTN2
Rhombotin-2

2

12

High-throughput

0.628

High

304625

SCAF4
SR-related and CTD-associated factor 4

1

9

High-throughput

0.618

High

854428

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

2

High-throughput

0.611

High

921126

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

2

High-throughput

0.611

High

552923

RFA2
Replication protein A 32 kDa subunit

2

8

High-throughput

0.584

High

651421

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

6

High-throughput

0.584

High

720667

RFA3
Replication protein A 14 kDa subunit

2

5

High-throughput

0.584

High

1137932

SLX4
Structure-specific endonuclease subunit SLX4

2

15

High-throughput

0.584

High

1137977

STRAP
Serine-threonine kinase receptor-associated protein

2

10

High-throughput

0.574

High

347020

MYC
Myc proto-oncogene protein

2

13

High-throughput

0.571

High

934232

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.569

High

1137966

WWOX
WW domain-containing oxidoreductase

2

3

High-throughput

0.555

High

473908

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

2

High-throughput

0.552

High

1137947

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

3

High-throughput

0.541

High

181423

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

3

High-throughput

0.536

High

446667

SNRPA
U1 small nuclear ribonucleoprotein A

1

9

High-throughput

0.536

High

448694

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

508564

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

539002

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

6

High-throughput

0.536

High

583724

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

3

High-throughput

0.536

High

642953

S10A4
Protein S100-A4

1

5

High-throughput

0.536

High

726876

FUS
RNA-binding protein FUS

1

15

High-throughput

0.536

High

911865

RUXF
Small nuclear ribonucleoprotein F

1

2

High-throughput

0.536

High

996706

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

998081

NCBP1
Nuclear cap-binding protein subunit 1

1

1

High-throughput

0.536

High

1084483

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

High-throughput

0.536

High

1087183

H2B2E
Histone H2B type 2-E

1

13

High-throughput

0.536

High

1137924

CTR9
RNA polymerase-associated protein CTR9 homolog

1

6

High-throughput

0.536

High

1137930

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

2

High-throughput

0.536

High

737859

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

12

Small-scale

0.535

High

1137922

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

2

High-throughput

0.533

High

1137971

PFD2
Prefoldin subunit 2

2

2

High-throughput

0.533

High

559130

H15
Histone H1.5

1

3

High-throughput

0.515

High

535861

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

1137935

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.513

High

905964

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

12

Small-scale

0.508

High

1137939

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.508

High

323823

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.489

High

416641

S10A6
Protein S100-A6

1

5

High-throughput

0.489

High

474821

POTEI
POTE ankyrin domain family member I

1

10

High-throughput

0.489

High

506821

SPTB1
Spectrin beta chain, erythrocytic

1

4

High-throughput

0.489

High

661294

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

871605

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.489

High

1051569

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.489

High

1137979

RPKL1
Ribosomal protein S6 kinase-like 1

1

5

High-throughput

0.489

High

214293

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.481

High

156026

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

10

High-throughput

0.479

High

162848

XPO1
Exportin-1

1

3

High-throughput

0.479

High

169868

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

8

High-throughput

0.479

High

179678

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

225386

MED14
Mediator of RNA polymerase II transcription subunit 14

1

14

High-throughput

0.479

High

244553

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

246576

MCE1
mRNA-capping enzyme

1

3

High-throughput

0.479

High

270198

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

2

High-throughput

0.479

High

295533

RECQ5
ATP-dependent DNA helicase Q5

1

13

High-throughput

0.479

High

295631

RMP
Unconventional prefoldin RPB5 interactor 1

1

2

High-throughput

0.479

High

317123

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

10

High-throughput

0.479

High

402731

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

2

High-throughput

0.479

High

487505

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

523811

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

583496

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

8

High-throughput

0.479

High

624925

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

10

High-throughput

0.479

High

666400

3MG
DNA-3-methyladenine glycosylase

1

1

Small-scale

0.479

High

676905

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

10

High-throughput

0.479

High

738848

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

7

High-throughput

0.479

High

801897

RECQ1
ATP-dependent DNA helicase Q1

1

11

High-throughput

0.479

High

808682

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

854311

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.479

High

864950

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

2

High-throughput

0.479

High

897537

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

3

High-throughput

0.479

High

917416

H4
Histone H4

1

5

High-throughput

0.479

High

944823

RED1
Double-stranded RNA-specific editase 1

1

8

High-throughput

0.479

High

1026438

RFA4
Replication protein A 30 kDa subunit

1

8

High-throughput

0.479

High

1037057

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

High-throughput

0.479

High

1055391

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.479

High

1056859

MDC1
Mediator of DNA damage checkpoint protein 1

1

17

High-throughput

0.479

High

1076161

MED1
Mediator of RNA polymerase II transcription subunit 1

1

11

High-throughput

0.479

High

1137926

SPT6H
Transcription elongation factor SPT6

1

4

High-throughput

0.479

High

1137928

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

High-throughput

0.479

High

1137929

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1137931

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1137933

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

1137938

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.479

High

1137940

DCPS
m7GpppX diphosphatase

1

4

High-throughput

0.479

High

1137945

MED10
Mediator of RNA polymerase II transcription subunit 10

1

2

High-throughput

0.479

High

1137946

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1137948

WWTR1
WW domain-containing transcription regulator protein 1

1

19

High-throughput

0.479

High

1137952

SFR19
Splicing factor, arginine/serine-rich 19

1

16

High-throughput

0.479

High

1137954

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

10

High-throughput

0.479

High

1137956

GPN1
GPN-loop GTPase 1

1

5

High-throughput

0.479

High

1137957

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.479

High

1137961

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

2

High-throughput

0.479

High

1137962

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

10

High-throughput

0.479

High

1137965

AATF
Protein AATF

1

1

High-throughput

0.479

High

1137967

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

7

High-throughput

0.479

High

1137969

UXT
Protein UXT

1

2

High-throughput

0.479

High

1137970

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1137973

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.479

High

1137974

FBW1A
F-box/WD repeat-containing protein 1A

1

10

High-throughput

0.479

High

1137976

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

7

High-throughput

0.479

High

1137978

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

5

High-throughput

0.479

High

825708

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.464

High

48681

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.458

High

313435

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.458

High

1137923

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

1137941

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

1137949

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.458

High

1137953

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

1137960

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

402135

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

100852

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

227718

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.437

High

301862

TRI37
E3 ubiquitin-protein ligase TRIM37

1

10

High-throughput

0.437

High

384982

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.437

High

779572

CCNF
Cyclin-F

1

3

High-throughput

0.437

High

932201

ACTC
Actin, alpha cardiac muscle 1

1

9

High-throughput

0.437

High

1137925

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1137927

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.437

High

1137934

SP7
Transcription factor Sp7

1

8

High-throughput

0.437

High

1137936

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.437

High

1137937

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.437

High

1137942

DAA10
Dynein axonemal assembly factor 10

1

2

High-throughput

0.437

High

1137944

B9D2
B9 domain-containing protein 2

1

1

High-throughput

0.437

High

1137950

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

1137951

RPAP3
RNA polymerase II-associated protein 3

1

11

High-throughput

0.437

High

1137959

PDRG1
p53 and DNA damage-regulated protein 1

1

2

High-throughput

0.437

High

1137963

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

1137968

PHRF1
PHD and RING finger domain-containing protein 1

1

15

High-throughput

0.437

High

1137972

GPN3
GPN-loop GTPase 3

1

5

High-throughput

0.437

High

1137975

NINL
Ninein-like protein

1

5

High-throughput

0.437

High

1137955

LN28A
Protein lin-28 homolog A

1

4

High-throughput

0.407

High


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Last updated: 15 Jul 2024