HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: CHD6 (Q8TD26)
Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)
Gene: CHD6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 2715
+	Hs
		935014 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD6_HUMAN (1-2715): 0: 3082: 100.00
+	Hs
		828213 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD3_HUMAN (19-1466): 0: 974: 25.26
+	Hs
		934705 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD3_HUMAN (19-1466): 0: 974: 25.26
+	Hs
		935016 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD5_HUMAN (19-1466): 0: 921: 22.98
+	Hs
		934770 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD4_HUMAN (32-1466): 0: 913: 24.27
+	Hs
		1059646 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		CHD4_HUMAN (32-1466): 0: 913: 24.27
+	Hs
		1059677 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		CHD4_HUMAN (32-1466): 0: 913: 24.27
+	Hs
		658641 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA1_HUMAN (340-1360): 0: 853: 27.11
+	Hs
		229341 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA5_HUMAN (347-1382): 0: 848: 26.50
+	Hs
		658647 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA1_HUMAN (340-1360): 0: 853: 27.11
+	Hs
		151392 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD1_HUMAN (67-1460): 0: 842: 25.85
+	Mm
		935460 H31_MOUSE (5-134): 1.29e-52: 164: 48.86		SMCA5_MOUSE (334-1382): 0: 849: 26.46
+	Hs
		229359 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA5_HUMAN (347-1382): 0: 848: 26.50
+	Hs
		151396 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD1_HUMAN (67-1460): 0: 842: 25.85
+	Hs
		151419 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		CHD1_HUMAN (67-1460): 0: 842: 25.85
+	Hs
		828410 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD7_HUMAN (1532-2715): 0: 780: 24.96
+	Hs
		935324 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD7_HUMAN (1532-2715): 0: 780: 24.96
+	Hs
		828175 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA2_HUMAN (75-1099): 0: 712: 24.17
+	Hs
		846743 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA2_HUMAN (75-1099): 0: 712: 24.17
+	Hs
		935262 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD8_HUMAN (2045-2271): 6.71e-44: 179: 23.65