HitPredict

Interactor 1: NU145 (P49687)
Nucleoporin NUP145 (EC 3.4.21.-) (Nuclear pore protein NUP145) [Cleaved into: Nucleoporin NUP145N (N-NUP145); Nucleoporin NUP145C (C-NUP145)]
Gene: NUP145

Interactor 2: IMB1 (Q06142)
Importin subunit beta-1 (Importin-95) (Karyopherin subunit beta-1) (Karyopherin-95)
Gene: KAP95

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	9864357, 8849456, 22357553, 17418788
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005643 - nuclear pore GO:0006606 - protein import into nucleus GO:0006607 - NLS-bearing protein import into nucleus GO:0008139 - nuclear localization sequence binding GO:0046822 - regulation of nucleocytoplasmic transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1317 Sc			1 861
+	Sc
		687969 NU145_YEAST (1-1317): 0: 1125: 100.00		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Sc
		971878 NU100_YEAST (45-542): 1.84e-14: 80.8: 14.10		IMB1_YEAST (1-861): 3.78e-177: 534: 100.00
+	Hs
		857978 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		IMB1_HUMAN (4-857): 7.07e-167: 509: 32.96
+	Xl
		853819 Q5EWX9_XENLA (1-330): 2.1e-13: 77.3: 16.09		IMB_XENLA (4-857): 2.14e-165: 505: 32.96
+	Hs
		834599 NU153_HUMAN (16-447): 4.54e-11: 70: 10.50		IMB1_HUMAN (4-857): 7.07e-167: 509: 32.96
+	Xl
		853820 Q6DCP4_XENLA (1-291): 5.23e-12: 72.3: 21.73		IMB_XENLA (4-857): 2.14e-165: 505: 32.96
+	At
		1321465 NUP1_ARATH (3-332): 1.74e-11: 71.2: 16.15		IMB1_ARATH (7-861): 1.11e-161: 495: 30.79
+	Hs
		178151 IF4G1_HUMAN (3-740): 5.58e-52: 203: 7.92		IPO8_HUMAN (1-860): 1.24e-95: 324: 11.86
+	Hs
		858024 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		TNPO1_HUMAN (12-807): 1.04e-126: 404: 15.37
+	Hs
		834652 NU153_HUMAN (16-447): 4.54e-11: 70: 10.50		TNPO1_HUMAN (12-807): 1.04e-126: 404: 15.37
+	Hs
		155553 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		TNPO2_HUMAN (15-807): 3.1e-120: 387: 15.44
+	Sc
		687986 NU100_YEAST (45-542): 1.84e-14: 80.8: 14.10		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Hs
		155550 NU153_HUMAN (16-447): 4.54e-11: 70: 10.50		TNPO2_HUMAN (15-807): 3.1e-120: 387: 15.44
+	Ce
		248185 Q9U3B9_CAEEL (104-343): 6.47e-18: 91.6: 21.81		O62332_CAEEL (2-823): 2.89e-99: 331: 16.17
+	Hs
		312215 NU153_HUMAN (16-447): 4.54e-11: 70: 10.50		IPO7_HUMAN (1-851): 2.31e-103: 345: 11.21
+	Ce
		248186 Q9XWK3_CAEEL (4-179): 3.66e-12: 72.6: 28.89		O62332_CAEEL (2-823): 2.89e-99: 331: 16.17
+	Ce
		136533 O01576_CAEEL (3-367): 1.3e-16: 87.8: 20.83		Q9N5V3_CAEEL (1-833): 3.22e-91: 313: 14.63
+	Ce
		1341732 Q9XWK3_CAEEL (4-179): 3.66e-12: 72.6: 28.89		Q9N5V3_CAEEL (1-833): 3.22e-91: 313: 14.63
+	Sc
		767712 NU100_YEAST (45-542): 1.84e-14: 80.8: 14.10		IMB4_YEAST (5-756): 1.06e-49: 192: 14.36
+	Hs
		127218 NU153_HUMAN (16-447): 4.54e-11: 70: 10.50		IPO5_HUMAN (4-604): 5.13e-11: 68.8: 9.23