HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	25963833, 33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 126
+	Hs
		832512 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B2F_HUMAN (1-126): 2.21e-54: 168: 98.41
+	Hs
		617935 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		832673 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.83
+	Hs
		241476 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21
+	Hs
		420814 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41
+	Hs
		832497 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		832624 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21
+	Hs
		707553 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		832280 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21
+	Hs
		832671 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1N_HUMAN (1-126): 3e-53: 164: 99.21
+	Hs
		832674 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1L_HUMAN (1-126): 2.18e-52: 163: 98.41
+	Hs
		832577 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24
+	Hs
		832629 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1A_HUMAN (1-126): 3.14e-46: 147: 84.25
+	Hs
		241460 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21
+	Hs
		708414 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		708456 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		707531 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		708493 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1A_HUMAN (1-126): 3.14e-46: 147: 84.25
+	Sc
		355815 MCM2_YEAST (11-821): 0: 819: 46.70		H2B2_YEAST (3-125): 5.51e-37: 124: 71.55
+	Sc
		355382 MCM2_YEAST (11-821): 0: 819: 46.70		H2B1_YEAST (3-125): 1.92e-36: 122: 71.55