HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	34133714
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 484 Hs			1 261
+	Hs
		266940 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		833711 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		267075 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		833938 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRS12_HUMAN (1-261): 8.09e-38: 135: 100.00
+	Hs
		833742 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		834087 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRS12_HUMAN (1-261): 8.09e-38: 135: 100.00
+	Hs
		266941 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		266942 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		833865 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		516362 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		516416 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		834022 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		834033 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516417 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		625466 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	At
		847172 AFC2_ARATH (115-481): 4.78e-121: 362: 42.59		SRC33_ARATH (5-254): 1.33e-21: 93: 29.20
+	Hs
		833887 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		834053 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	At
		847175 AFC3_ARATH (100-479): 1.15e-120: 360: 38.88		SRC30_ARATH (12-116): 2.12e-13: 70.1: 44.76
+	Dm
		834186 DOA_DROME (14-481): 1.35e-115: 361: 44.86		Q9V3T8_DROME (11-87): 1.48e-10: 60.8: 50.65