Protein: KDM5B
Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B)

Gene: KDM5B
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9UGL1

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003676 - nucleic acid binding
GO:0003677 - DNA binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110151

HDAC1
Histone deacetylase 1

3

16

Small-scale

0.857

High

129821

CBX4
E3 SUMO-protein ligase CBX4

2

4

Small-scale

0.806

High

247013

KDM1A
Lysine-specific histone demethylase 1A

1

7

Small-scale

0.724

High

273456

KDM4A
Lysine-specific demethylase 4A

1

12

High-throughput

0.691

High

1163264

H2B2E
Histone H2B type 2-E

1

10

High-throughput

0.691

High

938514

PAX9
Paired box protein Pax-9

3

5

Small-scale

0.661

High

442826

RB
Retinoblastoma-associated protein

3

4

Small-scale

0.640

High

1330841

TSYL6
Testis-specific Y-encoded-like protein 6

2

5

High-throughput

0.628

High

937664

FOXG1
Forkhead box protein G1

2

9

Small-scale

0.620

High

260577

BRD4
Bromodomain-containing protein 4

1

9

Small-scale

0.618

High

317023

MTA2
Metastasis-associated protein MTA2

1

5

Small-scale

0.618

High

941079

HDAC4
Histone deacetylase 4

1

18

Small-scale

0.618

High

998913

H31
Histone H3.1

1

20

Small-scale

0.618

High

1088600

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

3

Small-scale

0.618

High

1336768

RB15B
Putative RNA-binding protein 15B

1

3

Small-scale

0.618

High

1338779

ARI1B
AT-rich interactive domain-containing protein 1B

1

10

Small-scale

0.618

High

1347569

SMRC2
SWI/SNF complex subunit SMARCC2

1

18

Small-scale

0.618

High

1356777

HDAC7
Histone deacetylase 7

1

18

Small-scale

0.618

High

1368181

HDAC2
Histone deacetylase 2

1

16

Small-scale

0.618

High

1413357

MTA3
Metastasis-associated protein MTA3

1

8

Small-scale

0.618

High

1459582

HDAC5
Histone deacetylase 5

1

18

Small-scale

0.618

High

885442

HXA1
Homeobox protein Hox-A1

2

7

Small-scale

0.584

High

1155872

EZH2
Histone-lysine N-methyltransferase EZH2

2

18

Small-scale

0.584

High

1406114

CDX2
Homeobox protein CDX-2

2

9

Small-scale

0.584

High

352260

MBD3
Methyl-CpG-binding domain protein 3

1

2

Small-scale

0.561

High

1095106

KLF10
Krueppel-like factor 10

1

3

Small-scale

0.561

High

209349

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

8

High-throughput

0.536

High

321126

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.536

High

691518

1433T
14-3-3 protein theta

1

10

High-throughput

0.536

High

730328

1433B
14-3-3 protein beta/alpha

1

10

High-throughput

0.536

High

844057

HD
Huntingtin

1

2

High-throughput

0.536

High

966984

1433G
14-3-3 protein gamma

1

10

High-throughput

0.536

High

972100

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

990838

1433Z
14-3-3 protein zeta/delta

1

10

High-throughput

0.536

High

1049879

1433F
14-3-3 protein eta

1

10

High-throughput

0.536

High

1211283

SNPC4
snRNA-activating protein complex subunit 4

1

1

High-throughput

0.536

High

1459584

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.536

High

874012

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

1013116

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1313938

DHX37
Probable ATP-dependent RNA helicase DHX37

1

0

High-throughput

0.513

High

1431070

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

968025

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

Small-scale

0.501

High

886603

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.493

High

261013

SHOX2
Short stature homeobox protein 2

1

4

Small-scale

0.479

High

278445

NCOR1
Nuclear receptor corepressor 1

1

8

Small-scale

0.479

High

282197

MAF
Transcription factor Maf

1

3

Small-scale

0.479

High

285509

EED
Polycomb protein EED

1

14

Small-scale

0.479

High

320119

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

351471

ONEC2
One cut domain family member 2

1

2

Small-scale

0.479

High

373407

MYC
Myc proto-oncogene protein

1

5

Small-scale

0.479

High

397146

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

520427

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

533236

RARB
Retinoic acid receptor beta

1

19

Small-scale

0.479

High

634892

HXA5
Homeobox protein Hox-A5

1

6

Small-scale

0.479

High

681943

RBTN2
Rhombotin-2

1

7

Small-scale

0.479

High

894226

MEOX2
Homeobox protein MOX-2

1

8

Small-scale

0.479

High

905248

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

914829

DGKQ
Diacylglycerol kinase theta

1

1

Small-scale

0.479

High

1030951

MYT1
Myelin transcription factor 1

1

1

Small-scale

0.479

High

1066533

RBBP4
Histone-binding protein RBBP4

1

14

Small-scale

0.479

High

1086926

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.479

High

1101922

SKP2
S-phase kinase-associated protein 2

1

4

Small-scale

0.479

High

1137565

SUZ12
Polycomb protein SUZ12

1

6

Small-scale

0.479

High

1140990

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1159038

RBBP7
Histone-binding protein RBBP7

1

14

Small-scale

0.479

High

1229121

RNF43
E3 ubiquitin-protein ligase RNF43

1

5

Small-scale

0.479

High

1241300

TAF2
Transcription initiation factor TFIID subunit 2

1

1

Small-scale

0.479

High

1324607

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

Small-scale

0.479

High

1332955

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

4

Small-scale

0.479

High

1364919

NR4A3
Nuclear receptor subfamily 4 group A member 3

1

20

Small-scale

0.479

High

1405649

ELF4
ETS-related transcription factor Elf-4

1

11

Small-scale

0.479

High

1408311

FOXC2
Forkhead box protein C2

1

9

Small-scale

0.479

High

1434426

PRD13
PR domain zinc finger protein 13

1

2

Small-scale

0.479

High

1449482

BMP2K
BMP-2-inducible protein kinase

1

2

Small-scale

0.479

High

1458209

MBD2
Methyl-CpG-binding domain protein 2

1

2

Small-scale

0.479

High

1459579

DBNL
Drebrin-like protein

1

1

Small-scale

0.479

High

1459580

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.479

High

1459581

RCOR1
REST corepressor 1

1

8

Small-scale

0.479

High

71157

VGLL3
Transcription cofactor vestigial-like protein 3

1

0

Small-scale

0.458

High

139754

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

0

Small-scale

0.458

High

223402

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

277197

ZN217
Zinc finger protein 217

1

0

Small-scale

0.458

High

913266

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.458

High

1098537

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

0

Small-scale

0.458

High

1367951

AP2C
Transcription factor AP-2 gamma

1

0

Small-scale

0.458

High

1459583

AXIN2
Axin-2

1

0

Small-scale

0.458

High

1448529

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

322539

SLIK3
SLIT and NTRK-like protein 3

1

1

Small-scale

0.437

High

328478

CAC1H
Voltage-dependent T-type calcium channel subunit alpha-1H

1

1

Small-scale

0.437

High

1105258

S39A6
Zinc transporter ZIP6

1

1

Small-scale

0.437

High

1402081

PCX1
Pecanex-like protein 1

1

10

Small-scale

0.437

High

1419429

RHBT2
Rho-related BTB domain-containing protein 2

1

6

Small-scale

0.437

High

1434152

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1295125

F90A1
Protein FAM90A1

3

0

High-throughput

0.347

High

1145712

RCN1
Reticulocalbin-1

1

0

High-throughput

0.249

Low

1417223

T121B
Transmembrane protein 121B

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025