Protein: MBD2
Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)

Gene: MBD2
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q9UBB5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0003229 - ventricular cardiac muscle tissue development
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110142

HDAC1
Histone deacetylase 1

19

12

Small-scale

0.987

High

1295318

P66A
Transcriptional repressor p66-alpha

13

7

Small-scale

0.982

High

1368173

HDAC2
Histone deacetylase 2

11

12

Small-scale

0.975

High

1361028

P66B
Transcriptional repressor p66-beta

7

7

Small-scale

0.966

High

352258

MBD3
Methyl-CpG-binding domain protein 3

6

9

Small-scale

0.946

High

317018

MTA2
Metastasis-associated protein MTA2

6

16

Small-scale

0.931

High

1413355

MTA3
Metastasis-associated protein MTA3

2

16

High-throughput

0.789

High

1458208

MBD2
Methyl-CpG-binding domain protein 2

2

9

Small-scale

0.754

High

1159031

RBBP7
Histone-binding protein RBBP7

7

8

Small-scale

0.745

High

1066527

RBBP4
Histone-binding protein RBBP4

7

8

Small-scale

0.744

High

155365

CDKA1
Cyclin-dependent kinase 2-associated protein 1

6

5

Small-scale

0.727

High

1454894

ZN219
Zinc finger protein 219

4

3

High-throughput

0.694

High

1088597

CHD3
Chromodomain-helicase-DNA-binding protein 3

4

18

Small-scale

0.689

High

1133021

CHD4
Chromodomain-helicase-DNA-binding protein 4

4

18

Small-scale

0.686

High

519571

MYBB
Myb-related protein B

1

1

High-throughput

0.618

High

1102676

MTA1
Metastasis-associated protein MTA1

1

16

High-throughput

0.618

High

1407929

ANM1
Protein arginine N-methyltransferase 1

2

1

Small-scale

0.614

High

71482

P20L1
PHD finger protein 20-like protein 1

2

1

High-throughput

0.611

High

1054806

SUH
Recombining binding protein suppressor of hairless

2

2

High-throughput

0.611

High

1396141

Z512B
Zinc finger protein 512B

2

4

High-throughput

0.611

High

1421346

BC11B
B-cell lymphoma/leukemia 11B

2

8

High-throughput

0.611

High

1458215

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

5

High-throughput

0.611

High

1403034

SIN3A
Paired amphipathic helix protein Sin3a

2

4

Small-scale

0.606

High

911417

IMA5
Importin subunit alpha-5

2

4

High-throughput

0.601

High

1371935

STMN2
Stathmin-2

2

1

High-throughput

0.601

High

1458212

TRPS1
Zinc finger transcription factor Trps1

2

9

High-throughput

0.601

High

162726

ANM5
Protein arginine N-methyltransferase 5

2

1

Small-scale

0.584

High

1104689

IKZF1
DNA-binding protein Ikaros

2

3

Small-scale

0.584

High

1351291

CHD5
Chromodomain-helicase-DNA-binding protein 5

2

18

Small-scale

0.584

High

1410394

MEP50
Methylosome protein WDR77

2

1

Small-scale

0.584

High

1458214

IKZF3
Zinc finger protein Aiolos

2

3

Small-scale

0.584

High

1400977

PURB
Transcriptional regulator protein Pur-beta

2

0

High-throughput

0.580

High

1359991

MB3L1
Methyl-CpG-binding domain protein 3-like 1

1

9

Small-scale

0.573

High

1410425

HINFP
Histone H4 transcription factor

1

2

Small-scale

0.573

High

397124

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

685079

DNMT1
DNA

2

2

Small-scale

0.571

High

1160605

SMN
Survival motor neuron protein

1

0

High-throughput

0.558

High

1062690

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.549

High

1125303

FAK2
Protein-tyrosine kinase 2-beta

1

0

Small-scale

0.549

High

1439338

GPN1
GPN-loop GTPase 1

1

0

Small-scale

0.549

High

1058341

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.541

High

833788

KDM5C
Lysine-specific demethylase 5C

1

2

High-throughput

0.536

High

872836

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.536

High

1445900

HM20A
High mobility group protein 20A

1

6

High-throughput

0.536

High

1449305

SALL1
Sal-like protein 1

1

5

High-throughput

0.536

High

1458213

SALL4
Sal-like protein 4

1

5

High-throughput

0.536

High

1458217

TACC3
Transforming acidic coiled-coil-containing protein 3

1

0

Small-scale

0.529

High

1340907

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

9

Small-scale

0.527

High

1286226

RALYL
RNA-binding Raly-like protein

1

0

High-throughput

0.518

High

1390546

CDCA5
Sororin

1

0

High-throughput

0.513

High

1330693

BEND7
BEN domain-containing protein 7

1

1

High-throughput

0.494

High

902973

INSL3
Insulin-like 3

1

1

High-throughput

0.489

High

628853

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

168336

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.479

High

194378

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

210360

PHF1
PHD finger protein 1

1

3

High-throughput

0.479

High

243755

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.479

High

247003

KDM1A
Lysine-specific histone demethylase 1A

1

1

Small-scale

0.479

High

260565

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

274390

SIN3B
Paired amphipathic helix protein Sin3b

1

4

High-throughput

0.479

High

282323

SAP30
Histone deacetylase complex subunit SAP30

1

2

High-throughput

0.479

High

285503

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

299493

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

5

Small-scale

0.479

High

373382

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

401635

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

502159

H2AZ
Histone H2A.Z

1

3

High-throughput

0.479

High

520421

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

572260

TRI27
Zinc finger protein RFP

1

1

Small-scale

0.479

High

591868

H2AX
Histone H2AX

1

2

High-throughput

0.479

High

607181

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

703391

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

20

High-throughput

0.479

High

776143

SOX5
Transcription factor SOX-5

1

7

High-throughput

0.479

High

776261

SOX6
Transcription factor SOX-6

1

10

High-throughput

0.479

High

887289

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

980474

H4
Histone H4

1

2

High-throughput

0.479

High

998900

H31
Histone H3.1

1

5

High-throughput

0.479

High

1086830

BPTF
Nucleosome-remodeling factor subunit BPTF

1

10

High-throughput

0.479

High

1094744

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.479

High

1094822

CAF1B
Chromatin assembly factor 1 subunit B

1

1

High-throughput

0.479

High

1135283

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

20

High-throughput

0.479

High

1137561

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1155855

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

1161729

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1195609

ARI4B
AT-rich interactive domain-containing protein 4B

1

5

High-throughput

0.479

High

1198004

LIN52
Protein lin-52 homolog

1

1

High-throughput

0.479

High

1208648

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

3

High-throughput

0.479

High

1216635

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

1217516

CE350
Centrosome-associated protein 350

1

2

High-throughput

0.479

High

1312698

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.479

High

1328986

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.479

High

1335464

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

1353059

GEMI5
Gem-associated protein 5

1

1

High-throughput

0.479

High

1357128

ZN296
Zinc finger protein 296

1

8

High-throughput

0.479

High

1357165

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1392575

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

1398774

PWP2A
PWWP domain-containing protein 2A

1

2

High-throughput

0.479

High

1401055

PHF12
PHD finger protein 12

1

19

High-throughput

0.479

High

1420471

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1429913

SP130
Histone deacetylase complex subunit SAP130

1

3

High-throughput

0.479

High

1430826

BC11A
BCL11 transcription factor A

1

8

High-throughput

0.479

High

1435862

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

3

High-throughput

0.479

High

1458209

KDM5B
Lysine-specific demethylase 5B

1

2

Small-scale

0.479

High

1458210

HMGX4
HMG domain-containing protein 4

1

8

High-throughput

0.479

High

1458216

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.479

High

223394

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

667493

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

871802

RFX3
Transcription factor RFX3

1

0

High-throughput

0.458

High

1032061

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1445925

MLXPL
Carbohydrate-responsive element-binding protein

1

0

Small-scale

0.458

High

1453009

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

911141

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.445

High

1434120

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

442822

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

1458211

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.251

Low

339306

CV031
Uncharacterized protein C22orf31

1

0

High-throughput

0.249

Low

1451512

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025