HitPredict

Interactor 1: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Interactor 2: PSN2 (P49810)
Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
Gene: PSEN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.850

The method score is based on:

Property Details
Experiments 12471034, 21163940, 15474363
Identification Methods affinity chromatography technology, two hybrid, two hybrid array
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Presenilin~Presenilin
Common GO terms GO:0000139 - Golgi membrane
GO:0000776 - kinetochore
GO:0005743 - mitochondrial inner membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
and 26 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 467
Hs

1 448
+ Mm
+ Hs
+ Hs
+ Mm
+ Rn
+ Dm
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024