Protein: CSK
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)

Gene: CSK
Organism: Homo sapiens
Interactions: 161
UniProt ID: P41240

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834233

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

9

11

Small-scale

0.975

High

834197

TENS2
Tensin-2

6

20

High-throughput

0.952

High

362911

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.925

High

834199

TENS3
Tensin-3

5

20

High-throughput

0.919

High

834151

FRK
Tyrosine-protein kinase FRK

3

19

High-throughput

0.871

High

834204

PRAG1
Inactive tyrosine-protein kinase PRAG1

3

4

Small-scale

0.853

High

834149

CSK
Tyrosine-protein kinase CSK

3

19

Small-scale

0.840

High

834167

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.839

High

557151

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.834

High

834150

MATK
Megakaryocyte-associated tyrosine-protein kinase

2

19

High-throughput

0.811

High

711267

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.799

High

834214

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

20

High-throughput

0.789

High

834232

TENS1
Tensin-1

2

19

High-throughput

0.789

High

834196

KANK4
KN motif and ankyrin repeat domain-containing protein 4

2

5

High-throughput

0.783

High

193521

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

15

High-throughput

0.767

High

465442

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.766

High

240976

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.754

High

834157

ARRB1
Beta-arrestin-1

2

7

Small-scale

0.754

High

834177

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

20

High-throughput

0.754

High

834241

PTN22
Tyrosine-protein phosphatase non-receptor type 22

2

20

High-throughput

0.754

High

439980

LCK
Tyrosine-protein kinase Lck

2

18

High-throughput

0.737

High

440423

FYN
Tyrosine-protein kinase Fyn

2

19

Small-scale

0.737

High

461237

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.737

High

468145

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.737

High

539868

RALB
Ras-related protein Ral-B

2

17

High-throughput

0.737

High

729657

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.737

High

834164

1433G
14-3-3 protein gamma

2

20

High-throughput

0.737

High

834166

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.737

High

834168

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.737

High

834179

ZO1
Tight junction protein 1

2

19

High-throughput

0.737

High

834192

CDC37
Hsp90 co-chaperone Cdc37

2

12

High-throughput

0.737

High

834237

ZO2
Tight junction protein 2

2

17

High-throughput

0.737

High

471732

PTPRC
Receptor-type tyrosine-protein phosphatase C

2

20

Small-scale

0.712

High

834155

PAXI
Paxillin

5

20

Small-scale

0.702

High

291761

STK16
Serine/threonine-protein kinase 16

1

10

High-throughput

0.691

High

625234

CSK22
Casein kinase II subunit alpha'

1

16

High-throughput

0.691

High

834230

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

15

High-throughput

0.691

High

834240

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

20

High-throughput

0.691

High

641506

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.665

High

834176

CAV1
Caveolin-1

3

8

Small-scale

0.661

High

635685

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.647

High

834152

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.647

High

834228

SRCN1
SRC kinase signaling inhibitor 1

2

8

Small-scale

0.634

High

429457

JUN
Transcription factor Jun

2

4

Small-scale

0.631

High

439674

INSR
Insulin receptor

1

20

Small-scale

0.621

High

728082

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.618

High

732461

ARRB2
Beta-arrestin-2

1

7

Small-scale

0.618

High

834162

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

High-throughput

0.618

High

834178

FAK1
Focal adhesion kinase 1

1

19

Small-scale

0.618

High

834181

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

834202

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

834229

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

651201

CBL
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.611

High

834180

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

19

Small-scale

0.586

High

410683

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.575

High

443245

CDK1
Cyclin-dependent kinase 1

1

14

Small-scale

0.575

High

658811

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

High-throughput

0.575

High

658997

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

20

High-throughput

0.575

High

659075

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

20

High-throughput

0.575

High

834182

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

834183

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.575

High

834191

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

20

High-throughput

0.575

High

834193

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

20

High-throughput

0.575

High

834195

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

415401

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

420409

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

2

2

High-throughput

0.571

High

424808

ADT2
ADP/ATP translocase 2

2

2

High-throughput

0.571

High

534743

BIP
Endoplasmic reticulum chaperone BiP

2

20

High-throughput

0.571

High

536663

HSP7C
Heat shock cognate 71 kDa protein

2

13

High-throughput

0.571

High

600757

HSP76
Heat shock 70 kDa protein 6

2

13

High-throughput

0.571

High

697451

PYR1
Multifunctional protein CAD

2

4

High-throughput

0.571

High

727711

DNJA1
DnaJ homolog subfamily A member 1

2

5

High-throughput

0.571

High

731041

STIP1
Stress-induced-phosphoprotein 1

2

4

High-throughput

0.571

High

761571

HSP74
Heat shock 70 kDa protein 4

2

19

High-throughput

0.571

High

764266

CTNA1
Catenin alpha-1

2

4

High-throughput

0.571

High

801203

HSPA9
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

834170

TYB10
Thymosin beta-10

2

1

High-throughput

0.571

High

834171

TBA1B
Tubulin alpha-1B chain

2

11

High-throughput

0.571

High

834173

S25A3
Solute carrier family 25 member 3

2

4

High-throughput

0.571

High

834198

A16L1
Autophagy-related protein 16-1

2

9

High-throughput

0.571

High

834216

HS105
Heat shock protein 105 kDa

2

19

High-throughput

0.571

High

834220

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

9

High-throughput

0.571

High

834238

DPP2
Dipeptidyl peptidase 2

2

1

High-throughput

0.571

High

834210

LIRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

1

15

Small-scale

0.562

High

635828

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

2

Small-scale

0.561

High

834163

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

10

Small-scale

0.561

High

834172

DAB2
Disabled homolog 2

1

20

Small-scale

0.561

High

834188

DAG1
Dystroglycan 1

1

11

Small-scale

0.561

High

705264

GRN
Progranulin

2

0

High-throughput

0.547

High

834156

FAS
Fatty acid synthase

2

0

High-throughput

0.547

High

834160

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.547

High

834161

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.547

High

834153

SPB4
Serpin B4

1

2

High-throughput

0.536

High

834218

RAD50
DNA repair protein RAD50

1

14

High-throughput

0.536

High

834185

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

Small-scale

0.534

High

834221

DDT4L
DNA damage-inducible transcript 4-like protein

1

1

High-throughput

0.515

High

225543

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

834205

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

834175

ID3
DNA-binding protein inhibitor ID-3

1

1

Small-scale

0.508

High

192034

RGS16
Regulator of G-protein signaling 16

1

3

Small-scale

0.501

High

212711

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

20

Small-scale

0.501

High

249725

DOK2
Docking protein 2

1

20

Small-scale

0.501

High

269910

SDC3
Syndecan-3

1

6

Small-scale

0.501

High

460248

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

1

Small-scale

0.501

High

593732

PECA1
Platelet endothelial cell adhesion molecule

1

18

Small-scale

0.501

High

603868

CXA1
Gap junction alpha-1 protein

1

11

Small-scale

0.501

High

834215

SCRB1
Scavenger receptor class B member 1

1

6

Small-scale

0.501

High

834169

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

138002

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

324101

CE152
Centrosomal protein of 152 kDa

1

6

High-throughput

0.479

High

446730

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

588101

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

642684

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

10

High-throughput

0.479

High

791149

SYUA
Alpha-synuclein

1

7

High-throughput

0.479

High

834158

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

834159

R144A
E3 ubiquitin-protein ligase RNF144A

1

2

Small-scale

0.479

High

834206

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

Small-scale

0.479

High

834208

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

834209

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

834211

RIN3
Ras and Rab interactor 3

1

18

High-throughput

0.479

High

834213

PARD3
Partitioning defective 3 homolog

1

14

Small-scale

0.479

High

834217

DNSL2
Deoxyribonuclease-1-like 2

1

2

High-throughput

0.479

High

834219

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

834223

SCLT1
Sodium channel and clathrin linker 1

1

14

High-throughput

0.479

High

834226

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

834239

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.479

High

834242

TRAF6
TNF receptor-associated factor 6

1

17

Small-scale

0.479

High

834189

FHL2
Four and a half LIM domains protein 2

1

20

Small-scale

0.464

High

834236

ZN212
Zinc finger protein 212

1

5

Small-scale

0.464

High

834165

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

834174

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.458

High

834184

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

834212

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.458

High

834222

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

834225

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

281191

CDC45
Cell division control protein 45 homolog

1

2

Small-scale

0.457

High

834200

LAIR1
Leukocyte-associated immunoglobulin-like receptor 1

1

8

Small-scale

0.457

High

834201

SCIMP
SLP adapter and CSK-interacting membrane protein

1

1

Small-scale

0.457

High

142295

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.445

High

409298

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

834154

HSP77
Putative heat shock 70 kDa protein 7

1

14

High-throughput

0.445

High

834227

CD244
Natural killer cell receptor 2B4

1

13

Small-scale

0.445

High

297496

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.437

High

694817

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

767593

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

834190

PDIA5
Protein disulfide-isomerase A5

1

6

High-throughput

0.437

High

834194

CCD27
Coiled-coil domain-containing protein 27

1

6

High-throughput

0.437

High

834203

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

834224

CIC
Protein capicua homolog

1

14

High-throughput

0.437

High

834235

RRBP1
Ribosome-binding protein 1

1

7

High-throughput

0.437

High

834243

NCOR2
Nuclear receptor corepressor 2

1

3

High-throughput

0.437

High

834244

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.437

High

261116

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

598701

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

834207

POC5
Centrosomal protein POC5

1

0

High-throughput

0.426

High

330068

VENTX
Homeobox protein VENTX

1

15

High-throughput

0.407

High

834234

T161A
Transmembrane protein 161A

2

0

High-throughput

0.298

High

834187

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

834231

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

High-throughput

0.249

Low

834186

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025