HitPredict

Interactor 1: NU153 (P49790)
Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)
Gene: NUP153

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	28514442, 33961781, 35271311, 26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding GO:0016020 - membrane and 2 others more... GO:0031965 - nuclear membrane GO:0043657 - host cell
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1475 Hs			1 529
+	Hs
		134853 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		131403 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		238649 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	Hs
		168626 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA6_HUMAN (1-528): 9.99e-138: 410: 45.02
+	Hs
		834566 NU153_HUMAN (1-1475): 2.98e-176: 568: 100.00		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		834693 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		134854 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		131404 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		853440 RGPD5_HUMAN (1136-1440): 7.32e-39: 161: 16.72		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		152769 RGPD8_HUMAN (1136-1440): 1.82e-37: 156: 16.72		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		134921 RGPD4_HUMAN (1136-1440): 1.07e-38: 160: 16.39		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		834694 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		63862 RGPD3_HUMAN (1136-1440): 4.22e-38: 158: 16.39		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Dm
		1359634 Q9VGL0_DROME (152-1380): 3.82e-45: 181: 10.93		Q9V455_DROME (1-529): 3.23e-136: 406: 47.55
+	Sp
		293244 NU124_SCHPO (702-1470): 4.84e-40: 164: 11.67		IMA2_SCHPO (11-529): 2.95e-140: 417: 46.52
+	Hs
		131388 NU214_HUMAN (146-1306): 4.07e-29: 129: 11.13		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		134976 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		131525 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Sc
		691660 NUP2_YEAST (923-1394): 5.12e-24: 111: 17.83		IMA1_YEAST (2-529): 3.96e-141: 419: 43.83
+	Sc
		595062 NUP1_YEAST (863-1451): 7.24e-23: 108: 18.05		IMA1_YEAST (2-529): 3.96e-141: 419: 43.83