HitPredict

Interactor 1: NU153 (P49790)
Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)
Gene: NUP153

Interactor 2: SEH1 (Q96EE3)
Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)
Gene: SEH1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005829 - cytosol GO:0006913 - nucleocytoplasmic transport GO:0051028 - mRNA transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1475 Hs			1 360
+	Hs
		834813 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		SEH1_HUMAN (1-360): 1.71e-77: 243: 100.00
+	Hs
		727302 NU214_HUMAN (146-1306): 4.07e-29: 129: 11.13		SEH1_HUMAN (1-360): 1.71e-77: 243: 100.00
+	Hs
		1289605 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		SEH1_HUMAN (1-360): 1.71e-77: 243: 100.00
+	Hs
		65045 P121C_HUMAN (211-1269): 1.45e-20: 101: 9.16		SEH1_HUMAN (1-360): 1.71e-77: 243: 100.00
+	Sc
		595070 NUP1_YEAST (863-1451): 7.24e-23: 108: 18.05		SEC13_YEAST (7-319): 1.17e-73: 232: 29.84
+	Sp
		292982 NU189_SCHPO (852-1474): 2.24e-22: 107: 13.33		SEC13_SCHPO (4-320): 6.36e-73: 230: 28.44
+	Hs
		1056932 MDC1_HUMAN (67-796): 3.59e-56: 217: 14.00		SNR40_HUMAN (3-140): 3.35e-22: 98: 18.88
+	Hs
		834706 RBP2_HUMAN (573-1152): 6.9e-53: 207: 19.12		WDR5_HUMAN (253-360): 5.88e-19: 88.4: 18.52
+	Hs
		1281391 PRR36_HUMAN (694-1451): 1.9e-16: 87.5: 9.67		FBXW7_HUMAN (3-246): 5.14e-41: 154: 14.34
+	Dm
		1370295 Q9VLS7_DROME (83-1183): 2.17e-23: 110: 9.02		POC1_DROME (9-309): 3.76e-33: 128: 19.60
+	Hs
		1264784 TITIN_HUMAN (92-940): 3.34e-30: 133: 9.98		SNR40_HUMAN (3-140): 3.35e-22: 98: 18.88
+	Hs
		1288362 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		SNR40_HUMAN (3-140): 3.35e-22: 98: 18.88
+	Hs
		283055 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		CIAO1_HUMAN (57-321): 2.68e-22: 98: 20.71
+	Sp
		1013470 NU189_SCHPO (852-1474): 2.24e-22: 107: 13.33		SEH1_SCHPO (110-339): 1.59e-17: 84.3: 16.10
+	Hs
		878262 ZRAN1_HUMAN (589-796): 5.46e-22: 105: 16.89		SEC13_HUMAN (216-346): 5.58e-17: 82.6: 18.80
+	Hs
		1288235 P121A_HUMAN (102-1074): 5.78e-16: 86: 9.24		SNR40_HUMAN (3-140): 3.35e-22: 98: 18.88
+	Dm
		1358850 NUP98_DROME (905-1380): 3.22e-17: 90.2: 13.12		WDS_DROME (265-360): 3.21e-17: 83.7: 16.67
+	Sc
		595052 NUP1_YEAST (863-1451): 7.24e-23: 108: 18.05		SEH1_YEAST (185-338): 3.3e-10: 62.7: 16.05
+	Hs
		878229 P121A_HUMAN (102-1074): 5.78e-16: 86: 9.24		SEC13_HUMAN (216-346): 5.58e-17: 82.6: 18.80
+	Sc
		541905 NSP1_YEAST (861-1373): 2.64e-12: 73.7: 18.15		SEH1_YEAST (185-338): 3.3e-10: 62.7: 16.05