Protein: TNFL9
Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL)

Gene: TNFL9, TNFSF9
Organism: Homo sapiens
Interactions: 86
UniProt ID: P41273

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005125 - cytokine activity
GO:0005164 - tumor necrosis factor receptor binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834657

TNR9
Tumor necrosis factor receptor superfamily member 9

5

4

Small-scale

0.919

High

834665

CEA21
Cell adhesion molecule CEACAM21

3

1

High-throughput

0.861

High

377997

TNFA
Tumor necrosis factor

3

0

High-throughput

0.816

High

749313

TNFL8
Tumor necrosis factor ligand superfamily member 8

3

0

High-throughput

0.811

High

580740

PVR
Poliovirus receptor

2

0

High-throughput

0.770

High

834697

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.770

High

62101

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

1

High-throughput

0.726

High

127645

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

4

High-throughput

0.691

High

164905

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

4

High-throughput

0.691

High

596461

CTLA4
Cytotoxic T-lymphocyte protein 4

1

1

High-throughput

0.691

High

689807

CD27
CD27 antigen

1

4

High-throughput

0.691

High

731823

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.691

High

834660

CD226
CD226 antigen

1

1

High-throughput

0.691

High

834696

SLAF7
SLAM family member 7

1

3

High-throughput

0.691

High

627507

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

2

High-throughput

0.667

High

705948

CD1B
T-cell surface glycoprotein CD1b

3

3

High-throughput

0.667

High

834664

MICA
MHC class I polypeptide-related sequence A

3

3

High-throughput

0.667

High

749179

CD70
CD70 antigen

1

0

High-throughput

0.656

High

834674

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.656

High

834699

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.656

High

834676

S39A5
Zinc transporter ZIP5

3

0

High-throughput

0.634

High

834655

FCGRN
IgG receptor FcRn large subunit p51

2

2

High-throughput

0.628

High

834683

RAE1E
Retinoic acid early transcript 1E

2

5

High-throughput

0.628

High

834702

PCDGD
Protocadherin gamma-B1

2

1

High-throughput

0.628

High

338682

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.602

High

480403

MMP10
Stromelysin-2

2

0

High-throughput

0.602

High

533615

CLUS
Clusterin

2

0

High-throughput

0.602

High

749756

CADH5
Cadherin-5

2

0

High-throughput

0.602

High

834659

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.602

High

834666

CC50B
Cell cycle control protein 50B

2

0

High-throughput

0.602

High

834672

I27RA
Interleukin-27 receptor subunit alpha

2

0

High-throughput

0.602

High

564905

ICAM2
Intercellular adhesion molecule 2

2

0

High-throughput

0.585

High

834681

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.578

High

834701

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.578

High

302020

NCTR1
Natural cytotoxicity triggering receptor 1

1

1

High-throughput

0.536

High

520769

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

553342

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

2

High-throughput

0.536

High

553422

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

2

High-throughput

0.536

High

834658

CAD17
Cadherin-17

1

1

High-throughput

0.536

High

834670

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

1

High-throughput

0.536

High

834682

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

1

3

High-throughput

0.536

High

834689

FCRL2
Fc receptor-like protein 2

1

1

High-throughput

0.536

High

834692

PD1L2
Programmed cell death 1 ligand 2

1

1

High-throughput

0.536

High

834698

SLAF8
SLAM family member 8

1

3

High-throughput

0.536

High

834703

PCDA9
Protocadherin alpha-9

1

1

High-throughput

0.536

High

127815

CORT
Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17]

1

0

High-throughput

0.513

High

139186

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

328639

VAMP5
Vesicle-associated membrane protein 5

1

0

High-throughput

0.513

High

467397

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.513

High

472392

FGF4
Fibroblast growth factor 4

1

0

High-throughput

0.513

High

486545

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

547981

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

590258

MUC1
Mucin-1

1

0

High-throughput

0.513

High

624193

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

0

High-throughput

0.513

High

761186

RYK
Tyrosine-protein kinase RYK

1

0

High-throughput

0.513

High

834661

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

834662

OCLN
Occludin

1

0

High-throughput

0.513

High

834669

PLPP4
Phospholipid phosphatase 4

1

0

High-throughput

0.513

High

834671

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.513

High

834675

I20RB
Interleukin-20 receptor subunit beta

1

0

High-throughput

0.513

High

834677

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.513

High

834679

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.513

High

834684

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.513

High

834685

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.513

High

834686

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.513

High

834691

RARR2
Retinoic acid receptor responder protein 2

1

0

High-throughput

0.513

High

834693

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

834700

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.513

High

834704

ICOS
Inducible T-cell costimulator

1

0

High-throughput

0.513

High

217920

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

834656

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

Small-scale

0.479

High

126297

TLR4
Toll-like receptor 4

1

0

Small-scale

0.458

High

210175

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

0

Small-scale

0.458

High

379923

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

834663

MICB
MHC class I polypeptide-related sequence B

1

3

High-throughput

0.445

High

60708

F234B
Protein FAM234B

2

0

High-throughput

0.328

High

834680

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

834687

RUSF1
RUS family member 1

2

0

High-throughput

0.328

High

834694

SG196
Protein O-mannose kinase

2

0

High-throughput

0.298

High

834667

NHLC3
NHL repeat-containing protein 3

1

0

High-throughput

0.279

Low

834673

CP054
Transmembrane protein C16orf54

1

0

High-throughput

0.279

Low

834678

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

834690

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.279

Low

834695

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.279

Low

834688

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

834668

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025