Protein: HS2ST
Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-)

Gene: HS2ST, HS2ST1
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q7LGA3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004394 - heparan sulfate 2-O-sulfotransferase activity
GO:0010467 - gene expression
GO:0015014 - heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0015015 - heparan sulfate proteoglycan biosynthetic process, enzymatic modification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

777207

PEX19
Peroxisomal biogenesis factor 19

3

0

High-throughput

0.638

High

990513

CKAP4
Cytoskeleton-associated protein 4

3

0

High-throughput

0.638

High

1185603

DYM
Dymeclin

3

0

High-throughput

0.638

High

1185635

DIAP3
Protein diaphanous homolog 3

3

0

High-throughput

0.638

High

676565

CTR1
High affinity cationic amino acid transporter 1

2

1

High-throughput

0.628

High

871925

AT12A
Potassium-transporting ATPase alpha chain 2

3

3

High-throughput

0.609

High

1185644

P2RX2
P2X purinoceptor 2

2

1

High-throughput

0.574

High

382466

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

1

High-throughput

0.571

High

429079

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.541

High

163859

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.536

High

172081

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

530915

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

3

High-throughput

0.536

High

570339

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.536

High

626540

FPR2
N-formyl peptide receptor 2

1

3

High-throughput

0.536

High

654477

CALX
Calnexin

1

2

High-throughput

0.536

High

1185618

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.536

High

1185650

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.536

High

1185652

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.536

High

205585

TGON2
Trans-Golgi network integral membrane protein 2

2

1

High-throughput

0.533

High

170874

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.513

High

200042

GPAA1
Glycosylphosphatidylinositol anchor attachment 1 protein

1

0

High-throughput

0.513

High

306944

CSPG5
Chondroitin sulfate proteoglycan 5

1

0

High-throughput

0.513

High

318495

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.513

High

395034

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.513

High

495994

MGST1
Microsomal glutathione S-transferase 1

1

0

High-throughput

0.513

High

580183

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

0

High-throughput

0.513

High

585608

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

0

High-throughput

0.513

High

681505

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.513

High

833255

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

841998

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

0

High-throughput

0.513

High

997402

VAC14
Protein VAC14 homolog

1

0

High-throughput

0.513

High

1027499

STX5
Syntaxin-5

1

0

High-throughput

0.513

High

1069013

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

1102456

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.513

High

1136750

MTCL3
Microtubule cross-linking factor 3

1

0

High-throughput

0.513

High

1144478

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.513

High

1185604

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

0

High-throughput

0.513

High

1185605

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.513

High

1185608

NLGN2
Neuroligin-2

1

0

High-throughput

0.513

High

1185609

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1185612

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.513

High

1185617

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.513

High

1185620

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.513

High

1185626

PIGS
GPI transamidase component PIG-S

1

0

High-throughput

0.513

High

1185627

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1185629

SEC62
Translocation protein SEC62

1

0

High-throughput

0.513

High

1185631

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.513

High

1185633

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.513

High

1185634

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

1185640

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.513

High

158202

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.493

High

782434

P2RY2
P2Y purinoceptor 2

1

2

High-throughput

0.489

High

1069108

PON2
Serum paraoxonase/arylesterase 2

1

2

High-throughput

0.489

High

1069199

PON3
Serum paraoxonase/lactonase 3

1

2

High-throughput

0.489

High

1185615

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.489

High

1185639

DJC11
DnaJ homolog subfamily C member 11

1

1

High-throughput

0.489

High

1041903

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1185630

P2RX4
P2X purinoceptor 4

1

1

High-throughput

0.479

High

525971

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

813575

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

897178

TM258
Transmembrane protein 258

1

0

High-throughput

0.458

High

1185632

PIGU
Phosphatidylinositol glycan anchor biosynthesis class U protein

1

0

High-throughput

0.458

High

1185648

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

High-throughput

0.458

High

864890

SC5A3
Sodium/myo-inositol cotransporter

1

0

High-throughput

0.426

High

968173

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1185628

NMNA3
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

3

0

High-throughput

0.347

High

1185638

TBC23
TBC1 domain family member 23

3

0

High-throughput

0.347

High

1185607

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.328

High

1185621

TSN17
Tetraspanin-17

2

0

High-throughput

0.318

High

227884

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.305

High

59840

DEN11
DENN domain-containing protein 11

1

0

High-throughput

0.279

Low

131655

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

0

High-throughput

0.279

Low

182176

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

0

High-throughput

0.279

Low

207249

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

245363

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

430703

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.279

Low

1044831

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

0

High-throughput

0.279

Low

1082092

ASIC2
Acid-sensing ion channel 2

1

0

High-throughput

0.279

Low

1123626

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.279

Low

1153808

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

1168178

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1185606

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1185610

SCFD2
Sec1 family domain-containing protein 2

1

0

High-throughput

0.279

Low

1185611

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

1185616

YIPF5
Protein YIPF5

1

0

High-throughput

0.279

Low

1185619

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

1185623

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.279

Low

1185624

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.279

Low

1185625

LMF1
Lipase maturation factor 1

1

0

High-throughput

0.279

Low

1185636

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

High-throughput

0.279

Low

1185637

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

0

High-throughput

0.279

Low

1185641

USE1
Vesicle transport protein USE1

1

0

High-throughput

0.279

Low

1185643

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.279

Low

1185651

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

High-throughput

0.279

Low

1185614

KLK6
Kallikrein-6

1

0

High-throughput

0.268

Low

174997

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

127023

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.249

Low

441747

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

489124

H14
Histone H1.4

1

0

High-throughput

0.249

Low

553044

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

651547

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720784

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

779647

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

877780

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

980795

TLE3
Transducin-like enhancer protein 3

1

0

High-throughput

0.249

Low

1036690

SQSTM
Sequestosome-1

1

0

High-throughput

0.249

Low

1165710

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1170565

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1185613

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1185622

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1185642

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1185645

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.249

Low

1185646

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1185647

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

0

High-throughput

0.249

Low

1185649

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

478737

PNM6A
Paraneoplastic antigen-like protein 6A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024