HitPredict

Interactor 1: MEOX2 (P50222)
Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2)
Gene: MEOX2

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 522
+	Hs
		129540 MEOX2_HUMAN (1-304): 2.38e-58: 190: 100.00		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		129570 Q6FHY5_HUMAN (1-304): 1.09e-56: 186: 98.36		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		447245 HXB5_HUMAN (108-262): 1.13e-35: 131: 32.75		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		447285 HXB5_HUMAN (108-262): 1.13e-35: 131: 32.75		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		838380 MEOX2_HUMAN (1-304): 2.38e-58: 190: 100.00		TRI17_HUMAN (58-408): 7.59e-43: 160: 11.86
+	Hs
		447246 HXB5_HUMAN (108-262): 1.13e-35: 131: 32.75		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		1151316 Q6FHY5_HUMAN (1-304): 1.09e-56: 186: 98.36		TRI17_HUMAN (58-408): 7.59e-43: 160: 11.86
+	Hs
		723663 HXD12_HUMAN (95-253): 2.19e-34: 127: 28.96		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		838098 MEOX2_HUMAN (1-304): 2.38e-58: 190: 100.00		TRI50_HUMAN (60-403): 1.01e-39: 152: 14.12
+	Hs
		1151101 Q6FHY5_HUMAN (1-304): 1.09e-56: 186: 98.36		TRI50_HUMAN (60-403): 1.01e-39: 152: 14.12
+	Hs
		595623 HXA5_HUMAN (99-262): 1.06e-36: 133: 28.57		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		447281 HXB5_HUMAN (108-262): 1.13e-35: 131: 32.75		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		447220 HXB5_HUMAN (108-262): 1.13e-35: 131: 32.75		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		536721 HXB9_HUMAN (21-252): 3.38e-31: 118: 24.57		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		678807 HXA10_HUMAN (100-250): 4.39e-37: 138: 33.54		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		838275 MEOX2_HUMAN (1-304): 2.38e-58: 190: 100.00		RNF41_HUMAN (55-177): 2.33e-17: 84.9: 33.33
+	Hs
		1151238 Q6FHY5_HUMAN (1-304): 1.09e-56: 186: 98.36		RNF41_HUMAN (55-177): 2.33e-17: 84.9: 33.33
+	Hs
		838153 MEOX2_HUMAN (1-304): 2.38e-58: 190: 100.00		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		1151142 Q6FHY5_HUMAN (1-304): 1.09e-56: 186: 98.36		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		595607 HXA5_HUMAN (99-262): 1.06e-36: 133: 28.57		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26