Protein: STAT2
Signal transducer and activator of transcription 2 (p113)

Gene: STAT2
Organism: Homo sapiens
Interactions: 102
UniProt ID: P52630

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001932 - regulation of protein phosphorylation
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838030

STAT1
Signal transducer and activator of transcription 1-alpha/beta

23

16

Small-scale

0.988

High

913126

IRF9
Interferon regulatory factor 9

15

20

Small-scale

0.984

High

913152

CBP
CREB-binding protein

5

14

Small-scale

0.933

High

913129

EP300
Histone acetyltransferase p300

4

13

Small-scale

0.888

High

913154

IRF7
Interferon regulatory factor 7

4

20

Small-scale

0.881

High

363012

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

187319

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

2

1

High-throughput

0.811

High

913173

TRRAP
Transformation/transcription domain-associated protein

2

3

High-throughput

0.811

High

714597

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

20

Small-scale

0.789

High

838223

STAT6
Signal transducer and activator of transcription 6

2

16

Small-scale

0.776

High

873904

INAR2
Interferon alpha/beta receptor 2

8

2

Small-scale

0.753

High

913121

STAT2
Signal transducer and activator of transcription 2

2

17

Small-scale

0.749

High

602884

INAR1
Interferon alpha/beta receptor 1

7

15

Small-scale

0.745

High

913171

UBP18
Ubl carboxyl-terminal hydrolase 18

6

7

Small-scale

0.733

High

913123

EPHB4
Ephrin type-B receptor 4

1

11

High-throughput

0.691

High

488047

IFI6
Interferon alpha-inducible protein 6

4

1

Small-scale

0.676

High

488104

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

4

4

Small-scale

0.676

High

388173

GLPA
Glycophorin-A

3

2

High-throughput

0.662

High

913159

EP400
E1A-binding protein p400

3

6

High-throughput

0.662

High

425393

ISG15
Ubiquitin-like protein ISG15

3

2

Small-scale

0.640

High

913172

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

3

0

High-throughput

0.638

High

913144

DPP9
Dipeptidyl peptidase 9

3

0

High-throughput

0.634

High

281020

TACC1
Transforming acidic coiled-coil-containing protein 1

2

1

High-throughput

0.628

High

317149

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

2

4

High-throughput

0.628

High

504720

FBSP1
F-box/SPRY domain-containing protein 1

2

6

High-throughput

0.628

High

913140

KLH10
Kelch-like protein 10

2

1

High-throughput

0.628

High

913145

FBX11
F-box only protein 11

2

1

High-throughput

0.628

High

913163

ZN692
Zinc finger protein 692

2

1

High-throughput

0.628

High

913156

FBXW7
F-box/WD repeat-containing protein 7

2

4

Small-scale

0.620

High

658665

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

827716

STAT3
Signal transducer and activator of transcription 3

1

16

Small-scale

0.618

High

913133

IRF5
Interferon regulatory factor 5

1

20

Small-scale

0.618

High

913142

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

287888

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

0

High-throughput

0.602

High

913149

DOK4
Docking protein 4

2

2

High-throughput

0.594

High

560337

IFM1
Interferon-induced transmembrane protein 1

2

4

Small-scale

0.584

High

239555

MED14
Mediator of RNA polymerase II transcription subunit 14

1

6

Small-scale

0.578

High

913137

DCST1
E3 ubiquitin-protein ligase DCST1

2

0

Small-scale

0.576

High

913168

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

1

High-throughput

0.574

High

903289

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.561

High

913160

IWS1
Protein IWS1 homolog

1

1

High-throughput

0.541

High

605979

CAN2
Calpain-2 catalytic subunit

1

3

High-throughput

0.536

High

911191

IMA5
Importin subunit alpha-5

1

3

Small-scale

0.536

High

913162

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.536

High

519597

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.518

High

881643

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.518

High

624015

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

11

Small-scale

0.515

High

913131

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.515

High

913170

INT6
Integrator complex subunit 6

1

0

High-throughput

0.513

High

170026

AURKA
Aurora kinase A

1

3

Small-scale

0.501

High

891080

GSK3A
Glycogen synthase kinase-3 alpha

1

4

Small-scale

0.501

High

891389

GSK3B
Glycogen synthase kinase-3 beta

1

5

Small-scale

0.501

High

158942

CXL11
C-X-C motif chemokine 11

1

3

Small-scale

0.479

High

172602

XPO1
Exportin-1

1

2

High-throughput

0.479

High

415448

HSPB1
Heat shock protein beta-1

1

4

Small-scale

0.479

High

459508

PROF1
Profilin-1

1

1

High-throughput

0.479

High

461297

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

468207

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

488159

IFIT1
Antiviral innate immune response effector IFIT1

1

4

Small-scale

0.479

High

533906

IRF1
Interferon regulatory factor 1

1

20

Small-scale

0.479

High

555970

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

562842

CCL2
C-C motif chemokine 2

1

5

Small-scale

0.479

High

713968

PML
Protein PML

1

14

Small-scale

0.479

High

736882

GBP1
Guanylate-binding protein 1

1

2

Small-scale

0.479

High

798881

BRCA1
Breast cancer type 1 susceptibility protein

1

8

Small-scale

0.479

High

913124

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

5

Small-scale

0.479

High

913127

IFM3
Interferon-induced transmembrane protein 3

1

4

Small-scale

0.479

High

913130

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.479

High

913134

CUL1
Cullin-1

1

4

Small-scale

0.479

High

913135

CCDC6
Coiled-coil domain-containing protein 6

1

3

High-throughput

0.479

High

913138

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.479

High

913143

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

7

Small-scale

0.479

High

913146

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

7

Small-scale

0.479

High

913147

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.479

High

913148

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

Small-scale

0.479

High

913151

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

913153

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

Small-scale

0.479

High

913155

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

3

Small-scale

0.479

High

913158

PDLI2
PDZ and LIM domain protein 2

1

2

Small-scale

0.479

High

913165

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

913166

IL21
Interleukin-21

1

3

Small-scale

0.479

High

128878

MEN1
Menin

1

0

High-throughput

0.458

High

369168

OAS1
2'-5'-oligoadenylate synthase 1

1

0

Small-scale

0.458

High

402560

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

896498

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

913122

RCAN1
Calcipressin-1

1

0

Small-scale

0.458

High

913125

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

913169

TNIK
TRAF2 and NCK-interacting protein kinase

1

4

High-throughput

0.457

High

466879

ACM4
Muscarinic acetylcholine receptor M4

1

3

High-throughput

0.445

High

638401

FPR1
fMet-Leu-Phe receptor

1

8

High-throughput

0.445

High

913128

ACVR1
Activin receptor type-1

1

3

High-throughput

0.445

High

913132

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

913139

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.445

High

913150

LPAR1
Lysophosphatidic acid receptor 1

1

4

High-throughput

0.445

High

712721

IL12A
Interleukin-12 subunit alpha

1

1

Small-scale

0.437

High

913161

CCL19
C-C motif chemokine 19

1

5

Small-scale

0.437

High

913141

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

913164

SELO
Protein adenylyltransferase SelO, mitochondrial

2

0

High-throughput

0.328

High

913136

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

913167

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

913157

NXPE3
NXPE family member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025