Protein: SPICE
Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein)

Gene: SPICE, SPICE1
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q8N0Z3

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005814 - centriole
GO:0005819 - spindle
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1143415

PCM1
Pericentriolar material 1 protein

5

0

High-throughput

0.684

High

1322402

CE120
Centrosomal protein of 120 kDa

3

2

High-throughput

0.667

High

1322444

CE295
Centrosomal protein of 295 kDa

3

0

High-throughput

0.638

High

424524

PAI2
Plasminogen activator inhibitor 2

2

1

High-throughput

0.628

High

1063422

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.628

High

1215474

CE162
Centrosomal protein of 162 kDa

2

2

High-throughput

0.612

High

1226166

CP135
Centrosomal protein of 135 kDa

2

1

High-throughput

0.611

High

963440

STXB1
Syntaxin-binding protein 1

2

1

High-throughput

0.606

High

220094

TGM5
Protein-glutamine gamma-glutamyltransferase 5

2

0

High-throughput

0.602

High

1322459

MS18A
Protein Mis18-alpha

2

0

High-throughput

0.602

High

891240

GSK3A
Glycogen synthase kinase-3 alpha

2

1

Small-scale

0.601

High

134087

IPO5
Importin-5

2

1

High-throughput

0.588

High

1322463

WRP73
WD repeat-containing protein WRAP73

2

0

Small-scale

0.585

High

290073

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.585

High

322424

HAUS5
HAUS augmin-like complex subunit 5

2

0

High-throughput

0.585

High

1228546

HAUS3
HAUS augmin-like complex subunit 3

2

0

High-throughput

0.585

High

1322436

HAUS7
HAUS augmin-like complex subunit 7

2

0

High-throughput

0.585

High

1322440

HAUS8
HAUS augmin-like complex subunit 8

2

0

High-throughput

0.585

High

164009

NDC80
Kinetochore protein NDC80 homolog

2

1

High-throughput

0.584

High

1197010

AMOT
Angiomotin

2

2

High-throughput

0.584

High

1322446

VP33B
Vacuolar protein sorting-associated protein 33B

2

1

High-throughput

0.584

High

1322426

CEP63
Centrosomal protein of 63 kDa

2

1

High-throughput

0.571

High

323483

TRI37
E3 ubiquitin-protein ligase TRIM37

2

0

High-throughput

0.559

High

1322454

TRI36
E3 ubiquitin-protein ligase TRIM36

2

0

High-throughput

0.559

High

1322421

PTCD3
Small ribosomal subunit protein mS39

2

0

High-throughput

0.547

High

1322472

PA2G4
Proliferation-associated protein 2G4

2

0

High-throughput

0.547

High

445215

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

838375

STA5A
Signal transducer and activator of transcription 5A

1

1

High-throughput

0.536

High

895455

SPB8
Serpin B8

1

1

High-throughput

0.536

High

1219297

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.536

High

1322416

TRI52
E3 ubiquitin-protein ligase TRIM52

1

1

High-throughput

0.536

High

891671

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.515

High

194784

MEFV
Pyrin

1

0

High-throughput

0.513

High

341985

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

423677

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

563021

MYH6
Myosin-6

1

0

High-throughput

0.513

High

885837

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.513

High

994653

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.513

High

1117961

PKP1
Plakophilin-1

1

0

High-throughput

0.513

High

1322417

RGMA
Repulsive guidance molecule A

1

0

High-throughput

0.513

High

1322433

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.513

High

1322449

ARP5
Actin-related protein 5

1

0

High-throughput

0.513

High

1322464

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.513

High

1322473

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.513

High

706217

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1116366

RAB32
Ras-related protein Rab-32

1

1

High-throughput

0.489

High

122806

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.479

High

276325

HMMR
Hyaluronan mediated motility receptor

1

1

High-throughput

0.479

High

340179

PCNT
Pericentrin

1

1

High-throughput

0.479

High

349154

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.479

High

436940

K1C18
Keratin, type I cytoskeletal 18

1

1

High-throughput

0.479

High

542576

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.479

High

913147

STAT2
Signal transducer and activator of transcription 2

1

1

High-throughput

0.479

High

936803

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.479

High

1065735

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

1

High-throughput

0.479

High

1123711

DCTN1
Dynactin subunit 1

1

1

High-throughput

0.479

High

1140543

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1156148

ZYX
Zyxin

1

1

High-throughput

0.479

High

1186276

MA7D1
MAP7 domain-containing protein 1

1

3

High-throughput

0.479

High

1213176

CAMP1
Calmodulin-regulated spectrin-associated protein 1

1

1

High-throughput

0.479

High

1217477

CE350
Centrosome-associated protein 350

1

4

High-throughput

0.479

High

1228434

FTM
Protein fantom

1

1

High-throughput

0.479

High

1241548

CEP85
Centrosomal protein of 85 kDa

1

2

High-throughput

0.479

High

1252121

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1256512

CE128
Centrosomal protein of 128 kDa

1

2

High-throughput

0.479

High

1289942

LUZP1
Leucine zipper protein 1

1

1

High-throughput

0.479

High

1309930

MA7D3
MAP7 domain-containing protein 3

1

3

High-throughput

0.479

High

1314573

CKP2L
Cytoskeleton-associated protein 2-like

1

1

High-throughput

0.479

High

1322403

F184A
Protein FAM184A

1

1

High-throughput

0.479

High

1322408

IPO4
Importin-4

1

2

High-throughput

0.479

High

1322411

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.479

High

1322429

SPAG5
Sperm-associated antigen 5

1

1

High-throughput

0.479

High

1322430

MA7D2
MAP7 domain-containing protein 2

1

3

High-throughput

0.479

High

1322435

NP1L4
Nucleosome assembly protein 1-like 4

1

1

High-throughput

0.479

High

1322441

TCHP
Trichoplein keratin filament-binding protein

1

1

High-throughput

0.479

High

1322443

CP250
Centrosome-associated protein CEP250

1

1

High-throughput

0.479

High

1322452

CPAP
Centrosomal P4.1-associated protein

1

2

High-throughput

0.479

High

1322455

LATS2
Serine/threonine-protein kinase LATS2

1

1

High-throughput

0.479

High

1322461

CEP72
Centrosomal protein of 72 kDa

1

1

High-throughput

0.479

High

1322468

MTUS1
Microtubule-associated tumor suppressor 1

1

4

High-throughput

0.479

High

1322470

CP131
Centrosomal protein of 131 kDa

1

1

High-throughput

0.479

High

60796

CCD66
Coiled-coil domain-containing protein 66

1

0

High-throughput

0.458

High

136110

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.458

High

173053

XPO1
Exportin-1

1

0

High-throughput

0.458

High

176849

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.458

High

283705

GPC4
Glypican-4

1

0

High-throughput

0.458

High

285688

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.458

High

414189

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

424433

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

437266

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

475630

K1C19
Keratin, type I cytoskeletal 19

1

0

High-throughput

0.458

High

530065

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

553231

KCRB
Creatine kinase B-type

1

0

High-throughput

0.458

High

573859

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.458

High

629956

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

642967

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

834340

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

878509

PAXI
Paxillin

1

0

High-throughput

0.458

High

946430

MTPN
Myotrophin

1

0

High-throughput

0.458

High

966598

1433G
14-3-3 protein gamma

1

0

High-throughput

0.458

High

1045504

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1086508

TROAP
Tastin

1

0

High-throughput

0.458

High

1113657

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1145004

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1169013

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.458

High

1177964

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1178601

KIF7
Kinesin-like protein KIF7

1

0

High-throughput

0.458

High

1185278

F161A
Protein FAM161A

1

0

High-throughput

0.458

High

1193441

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.458

High

1193650

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.458

High

1193703

C2CD3
C2 domain-containing protein 3

1

0

High-throughput

0.458

High

1198453

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.458

High

1213066

RHG21
Rho GTPase-activating protein 21

1

0

High-throughput

0.458

High

1226575

MAP1S
Microtubule-associated protein 1S

1

0

High-throughput

0.458

High

1241090

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

0

High-throughput

0.458

High

1256393

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.458

High

1278193

CLAP1
CLIP-associating protein 1

1

0

High-throughput

0.458

High

1278407

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.458

High

1308084

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.458

High

1311937

SKA3
Spindle and kinetochore-associated protein 3

1

0

High-throughput

0.458

High

1322401

TEX9
Testis-expressed protein 9

1

0

High-throughput

0.458

High

1322404

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.458

High

1322405

ARI1B
AT-rich interactive domain-containing protein 1B

1

0

High-throughput

0.458

High

1322406

NEDD1
Protein NEDD1

1

0

High-throughput

0.458

High

1322409

SKA2
Spindle and kinetochore-associated protein 2

1

0

High-throughput

0.458

High

1322413

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.458

High

1322414

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1322418

SKA1
SKA complex subunit 1

1

0

High-throughput

0.458

High

1322419

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.458

High

1322420

TBC31
TBC1 domain family member 31

1

0

High-throughput

0.458

High

1322423

CEP95
Centrosomal protein of 95 kDa

1

0

High-throughput

0.458

High

1322434

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.458

High

1322438

CCD77
Coiled-coil domain-containing protein 77

1

0

High-throughput

0.458

High

1322445

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

1322447

HAUS4
HAUS augmin-like complex subunit 4

1

0

High-throughput

0.458

High

1322451

EMAL4
Echinoderm microtubule-associated protein-like 4

1

0

High-throughput

0.458

High

1322456

DIAP3
Protein diaphanous homolog 3

1

0

High-throughput

0.458

High

1322458

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.458

High

1322467

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.458

High

1322469

CC14A
Dual specificity protein phosphatase CDC14A

1

0

High-throughput

0.458

High

1322471

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.458

High

1322475

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.458

High

1322476

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.458

High

189216

IPO8
Importin-8

1

1

High-throughput

0.437

High

334833

IPO7
Importin-7

1

2

High-throughput

0.437

High

1039531

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.437

High

1124491

MAP7
Ensconsin

1

5

High-throughput

0.437

High

1322457

TXLNG
Gamma-taxilin

1

1

High-throughput

0.437

High

1199579

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

246753

KDM1A
Lysine-specific histone demethylase 1A

4

0

High-throughput

0.360

High

1242342

PLBL1
Phospholipase B-like 1

2

0

High-throughput

0.328

High

1322437

KXDL1
KxDL motif-containing protein 1

2

0

High-throughput

0.313

High

1322453

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.305

High

469131

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.279

Low

1322410

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

1322428

PHF12
PHD finger protein 12

1

0

High-throughput

0.279

Low

1322466

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

124939

GTPB1
GTP-binding protein 1

1

0

High-throughput

0.249

Low

194264

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

278892

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.249

Low

303594

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.249

Low

338150

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.249

Low

446441

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

589132

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695917

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

794543

RBMX
RNA-binding motif protein, X chromosome

1

0

High-throughput

0.249

Low

829113

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.249

Low

938378

NH2L1
NHP2-like protein 1

1

0

High-throughput

0.249

Low

956383

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.249

Low

988154

TRA2B
Transformer-2 protein homolog beta

1

0

High-throughput

0.249

Low

1065293

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.249

Low

1092585

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.249

Low

1204212

PDZ11
PDZ domain-containing protein 11

1

0

High-throughput

0.249

Low

1227043

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1322407

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.249

Low

1322412

PHIP
PH-interacting protein

1

0

High-throughput

0.249

Low

1322422

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.249

Low

1322424

ZC21A
Zinc finger C2HC domain-containing protein 1A

1

0

High-throughput

0.249

Low

1322425

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

1322427

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.249

Low

1322431

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.249

Low

1322432

RBM15
RNA-binding protein 15

1

0

High-throughput

0.249

Low

1322439

NOL10
Nucleolar protein 10

1

0

High-throughput

0.249

Low

1322442

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.249

Low

1322448

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.249

Low

1322450

PKHA5
Pleckstrin homology domain-containing family A member 5

1

0

High-throughput

0.249

Low

1322460

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.249

Low

1322462

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.249

Low

1322465

RALY
RNA-binding protein Raly

1

0

High-throughput

0.249

Low

1322474

NOP58
Nucleolar protein 58

1

0

High-throughput

0.249

Low

1322477

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

1211865

CHCH9
Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial

1

0

High-throughput

0.232

Low

1322415

NXPE3
NXPE family member 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025