HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 217
+	Mm
		760474 DYN2_MOUSE (1-870): 0: 1057: 98.16		GRB2_MOUSE (1-216): 3.23e-69: 212: 59.72
+	Hs
		840663 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Hs
		337399 DYN2_HUMAN (1-870): 0: 1057: 100.00		ABL1_HUMAN (3-180): 4.01e-52: 182: 31.69
+	Hs
		442794 DYN2_HUMAN (1-870): 0: 1057: 100.00		HCK_HUMAN (4-158): 6.34e-52: 176: 32.74
+	Mm
		760450 DYN1_MOUSE (1-844): 0: 1003: 79.23		GRB2_MOUSE (1-216): 3.23e-69: 212: 59.72
+	Hs
		411645 DYN2_HUMAN (1-870): 0: 1057: 100.00		LCK_HUMAN (4-204): 1.02e-41: 149: 26.98
+	Hs
		433651 DYN2_HUMAN (1-870): 0: 1057: 100.00		LYN_HUMAN (4-204): 4.34e-36: 134: 25.58
+	Hs
		337437 DYN1_HUMAN (1-846): 0: 1002: 79.04		ABL1_HUMAN (3-180): 4.01e-52: 182: 31.69
+	Hs
		840840 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN2_HUMAN (106-215): 4.33e-14: 72.7: 24.11
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (67-215): 1.06e-13: 71.5: 13.46
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (50-215): 1.73e-13: 70.7: 12.36
+	Hs
		840878 DYN2_HUMAN (1-870): 0: 1057: 100.00		CD2AP_HUMAN (3-58): 7.12e-13: 68.8: 28.07
+	Hs
		412090 DYN2_HUMAN (1-870): 0: 1057: 100.00		FYN_HUMAN (154-215): 1.46e-12: 67.7: 31.25
+	Rn
		192740 DYN2_RAT (1-870): 0: 1053: 98.05		SRBS2_RAT (66-216): 2.85e-13: 70: 21.57
+	Hs
		275181 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRAP2_HUMAN (3-55): 1.64e-11: 64.4: 33.96
+	Hs
		522862 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRC_HUMAN (141-214): 3.55e-11: 63.8: 21.05
+	Hs
		557664 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK1_HUMAN (5-145): 1.04e-23: 99: 35.47
+	Mm
		223006 DYN1_MOUSE (1-844): 0: 1003: 79.23		NCK2_MOUSE (6-140): 3.08e-20: 89.4: 34.97
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (67-215): 1.06e-13: 71.5: 13.46
+	Hs
		522926 DYN1_HUMAN (1-846): 0: 1002: 79.04		SRC_HUMAN (141-214): 3.55e-11: 63.8: 21.05