HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	21900206, 15834155, 16696976
Identification Methods	two hybrid, pull down, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~RhoGEF, PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0043005 - neuron projection and 1 others more... GO:0055037 - recycling endosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 1721
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Hs
		983379 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Rn
		599413 DYN1_RAT (1-846): 0: 994: 78.57		ITSN1_RAT (1-1721): 0: 853: 92.27
+	Hs
		840840 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Ce
		760500 DYN1_CAEEL (3-823): 0: 899: 61.86		VAV_CAEEL (1160-1566): 7.98e-66: 245: 16.74
+	Hs
		787872 DYN2_HUMAN (1-870): 0: 1057: 100.00		EPS15_HUMAN (529-913): 1.04e-10: 68.9: 12.69
+	Hs
		840719 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (1079-1218): 3.12e-09: 63.9: 28.57
+	Hs
		557664 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Dm
		112570 DYN_DROME (6-842): 0: 928: 66.23		M9ND00_DROME (713-1252): 3.91e-15: 83.6: 12.73
+	Dm
		247616 DYN_DROME (6-842): 0: 928: 66.23		O61618_DROME (709-1252): 1.69e-14: 81.7: 12.68
+	Dm
		91155 DYN_DROME (6-842): 0: 928: 66.23		E3CTP7_DROME (25-165): 8.27e-11: 69.2: 22.37
+	Ce
		760510 DYN1_CAEEL (3-823): 0: 899: 61.86		Q9U2T9_CAEEL (708-1241): 6.47e-10: 66.6: 11.25