HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: SH319 (Q5HYK7)
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)
Gene: SH3D19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 790
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (417-786): 3.11e-27: 121: 18.20
+	Hs
		840663 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Mm
		760474 DYN2_MOUSE (1-870): 0: 1057: 98.16		GRB2_MOUSE (498-718): 2.72e-24: 103: 20.27
+	Hs
		840686 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRAP_HUMAN (501-719): 3.12e-22: 97.9: 25.91
+	Rn
		192740 DYN2_RAT (1-870): 0: 1053: 98.05		SRBS2_RAT (269-552): 1.32e-19: 96.4: 20.18
+	Hs
		840878 DYN2_HUMAN (1-870): 0: 1057: 100.00		CD2AP_HUMAN (300-607): 3.02e-17: 88.2: 10.87
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (93-789): 1.17e-16: 87.1: 11.28
+	Hs
		840739 DYN2_HUMAN (1-870): 0: 1057: 100.00		DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22
+	Hs
		840840 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN2_HUMAN (680-790): 7.11e-16: 84.4: 24.78
+	Hs
		275181 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRAP2_HUMAN (305-554): 1.65e-16: 83.6: 15.20
+	Mm
		760481 DYN2_MOUSE (1-870): 0: 1057: 98.16		SH3K1_MOUSE (309-686): 3.68e-13: 75.1: 11.84
+	Hs
		840786 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		557664 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		840747 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3R1_HUMAN (244-550): 1.54e-09: 63.7: 11.61
+	Hs
		209034 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		840811 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRBS1_HUMAN (672-788): 2.98e-09: 62.8: 33.07
+	Mm
		760450 DYN1_MOUSE (1-844): 0: 1003: 79.23		GRB2_MOUSE (498-718): 2.72e-24: 103: 20.27
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (93-789): 1.17e-16: 87.1: 11.28
+	Mm
		223006 DYN1_MOUSE (1-844): 0: 1003: 79.23		NCK2_MOUSE (346-572): 9.48e-15: 79: 13.25
+	Mm
		760462 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3K1_MOUSE (309-686): 3.68e-13: 75.1: 11.84