HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: DNMBP (Q6XZF7)
Dynamin-binding protein (Scaffold protein Tuba)
Gene: DNMBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	32203420, 33961781, unassigned2213
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~RhoGEF, PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0045202 - synapse GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 1577
+	Hs
		983387 DYN1_HUMAN (1-846): 0: 1002: 79.04		DNMBP_HUMAN (1-1577): 0: 917: 100.00
+	Mm
		139029 DYN2_MOUSE (1-870): 0: 1057: 98.16		BIN1_MOUSE (994-1575): 1.88e-75: 265: 16.06
+	Hs
		131222 DYN2_HUMAN (1-870): 0: 1057: 100.00		BIN1_HUMAN (994-1574): 3.96e-74: 261: 16.98
+	Rn
		139974 DYN2_RAT (1-870): 0: 1053: 98.05		AMPH_RAT (995-1361): 1.7e-63: 232: 19.16
+	Hs
		840758 DYN2_HUMAN (1-870): 0: 1057: 100.00		TIAM2_HUMAN (677-969): 3.37e-56: 217: 25.08
+	Mm
		139028 DYN1_MOUSE (1-844): 0: 1003: 79.23		BIN1_MOUSE (994-1575): 1.88e-75: 265: 16.06
+	Hs
		131238 DYN1_HUMAN (1-846): 0: 1002: 79.04		BIN1_HUMAN (994-1574): 3.96e-74: 261: 16.98
+	Rn
		139987 DYN1_RAT (1-846): 0: 994: 78.57		BIN1_RAT (994-1575): 5.76e-74: 260: 15.91
+	Rn
		139973 DYN1_RAT (1-846): 0: 994: 78.57		AMPH_RAT (995-1361): 1.7e-63: 232: 19.16
+	Hs
		840719 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (3-127): 1.19e-14: 81.4: 24.62
+	Hs
		840840 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN2_HUMAN (2-104): 1.6e-13: 78.2: 20.39
+	Mm
		760481 DYN2_MOUSE (1-870): 0: 1057: 98.16		SH3K1_MOUSE (158-298): 4.21e-12: 73.2: 30.26
+	Hs
		840786 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3K1_HUMAN (158-324): 3.67e-12: 73.2: 28.09
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (6-104): 1.33e-11: 72.1: 19.19
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (6-104): 1.01e-10: 69: 19.19
+	Mm
		760462 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3K1_MOUSE (158-298): 4.21e-12: 73.2: 30.26
+	Hs
		983399 DYN1_HUMAN (1-846): 0: 1002: 79.04		SH3K1_HUMAN (158-324): 3.67e-12: 73.2: 28.09
+	Hs
		983379 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (6-104): 1.33e-11: 72.1: 19.19
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (6-104): 1.01e-10: 69: 19.19
+	Rn
		599413 DYN1_RAT (1-846): 0: 994: 78.57		ITSN1_RAT (6-104): 9.79e-11: 69: 19.19