HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	32203420, 22558309
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~RhoGEF, PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 1697
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (2-1693): 0: 861: 56.37
+	Hs
		983379 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (2-1693): 0: 861: 56.37
+	Rn
		599413 DYN1_RAT (1-846): 0: 994: 78.57		ITSN1_RAT (2-1693): 0: 854: 56.08
+	Hs
		787872 DYN2_HUMAN (1-870): 0: 1057: 100.00		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Ce
		760500 DYN1_CAEEL (3-823): 0: 899: 61.86		VAV_CAEEL (1141-1621): 1.34e-70: 260: 16.44
+	Hs
		840719 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (1035-1211): 6.54e-11: 69.3: 28.26
+	Dm
		112570 DYN_DROME (6-842): 0: 928: 66.23		M9ND00_DROME (1-447): 2.52e-32: 139: 14.35
+	Dm
		91155 DYN_DROME (6-842): 0: 928: 66.23		E3CTP7_DROME (216-327): 1.05e-15: 85.2: 34.82
+	Dm
		247616 DYN_DROME (6-842): 0: 928: 66.23		O61618_DROME (796-1047): 2.33e-14: 81: 20.08
+	Ce
		760510 DYN1_CAEEL (3-823): 0: 899: 61.86		Q9U2T9_CAEEL (666-1214): 4.67e-17: 89.9: 13.17