HitPredict

Interactor 1: UBC9 (P50623)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (Ubiquitin carrier protein 9) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)
Gene: UBC9

Interactor 2: UBA2 (P52488)
Ubiquitin-activating enzyme E1-like (Polymerase-interacting protein 2) (SMT3-activating enzyme subunit 2)
Gene: UBA2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	15738391, 21518767, 12354763, 26633173, 9341106, 21209884
Identification Methods	pull down, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 157 Sc			1 636
+	Hs
		930429 UBC9_HUMAN (1-156): 5.53e-69: 207: 56.41		SAE2_HUMAN (9-636): 0: 552: 32.57
+	Hs
		1282360 UB2E3_HUMAN (3-156): 1.16e-67: 205: 31.17		SAE2_HUMAN (9-636): 0: 552: 32.57
+	Dm
		1181395 Q7KNM2_DROME (1-156): 5.99e-73: 217: 53.85		Q7KUA4_DROME (10-614): 2.31e-176: 519: 29.43
+	At
		1115004 SCE1_ARATH (2-155): 7.8e-73: 216: 59.74		SAE2_ARATH (16-544): 2.91e-160: 478: 32.68
+	Hs
		919796 UB2D2_HUMAN (4-156): 2.79e-73: 217: 32.68		UBA3_HUMAN (293-526): 4.98e-48: 176: 14.98
+	Hs
		607190 UB2D4_HUMAN (4-156): 2.62e-74: 220: 33.33		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Hs
		607026 UB2D1_HUMAN (4-156): 1.54e-73: 218: 33.99		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Hs
		607050 UB2D2_HUMAN (4-156): 2.79e-73: 217: 32.68		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Sc
		608711 UBC9_YEAST (1-157): 4.84e-76: 225: 100.00		UBA1_YEAST (4-154): 5.89e-29: 125: 20.40
+	Hs
		607039 UB2D3_HUMAN (4-156): 3.32e-72: 215: 32.68		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Hs
		607055 UBC9_HUMAN (1-156): 5.53e-69: 207: 56.41		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Sc
		549788 UBC4_YEAST (1-156): 3.15e-72: 215: 33.33		UBA1_YEAST (4-154): 5.89e-29: 125: 20.40
+	Hs
		607136 UB2E2_HUMAN (3-156): 4.04e-68: 206: 31.17		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Hs
		607129 UB2E3_HUMAN (3-156): 1.16e-67: 205: 31.17		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Hs
		48104 UB2D1_HUMAN (4-156): 1.54e-73: 218: 33.99		UBA6_HUMAN (4-328): 4.2e-27: 119: 12.57
+	Hs
		48107 UB2D2_HUMAN (4-156): 2.79e-73: 217: 32.68		UBA6_HUMAN (4-328): 4.2e-27: 119: 12.57
+	Hs
		607023 UBE2A_HUMAN (1-154): 1.04e-66: 201: 38.96		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Hs
		607028 UB2E1_HUMAN (3-156): 3.29e-66: 201: 31.82		UBA1_HUMAN (4-153): 7.74e-32: 134: 20.00
+	Hs
		48106 UB2D3_HUMAN (4-156): 3.32e-72: 215: 32.68		UBA6_HUMAN (4-328): 4.2e-27: 119: 12.57
+	Sp
		293848 UBC4_SCHPO (4-156): 3.4e-72: 215: 33.33		UBA1_SCHPO (4-153): 3.46e-24: 110: 16.67